If an autoimmune condition affects Type 3 immunity, therapies such as anti-IL-17 or anti-IL-23 may be...

If an autoimmune condition affects Type 3 immunity, therapies such as anti-IL-17 or anti-IL-23 may be effective. True or False?

Expert Solution

True

Psoriasis is an inflammatory skin disease, and psoriatic arthritis (PsA) is an inflammatory arthritis, which share clinical , genetic and pathogenic factors and it is summed as one disease as psoriatic diseases.
Interleukin (IL)-17 plays a major role in the development of both psoriasis and PsA.
Interleukin (IL)-23 is important in the proliferation and maintenance of IL-17 , and therefore, cytokines of the IL-23/ IL-17 axis attracted much interest as therapeutic targets in psoriais and PsA.
Therapeutic agents targeting the IL-23/IL-17 axis have been proven to be very effective in psoriais and PsA.
Some agents target IL-23 and other IL-17 including , anti-IL-12/IL-23 p40 (ustekinumab, briankizumab), anti-IL-23p19 (guselkumab, tildrakizumab, risankizumab, brazikumab, mirikizumab), anti-IL-17A (secukinumab, ixekizumab), dual anti-IL-17A and anti-IL-17F (bimekizumab), or anti-IL-17 receptor (brodalumab) monoclonal antibodies

Sydney Mullin answered 1 year ago

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