Describe two conditions involving cellular parameters which would cause the oxygen dissociation curve to right shift....

Describe two conditions involving cellular parameters which would cause the oxygen dissociation curve to right shift.

How would that solve an oxygen problem in the cell?

Expert Solution

Oxygen dissociation curve is a graphical representation Between the partila pressure of oxygen (po2) and the hemoglobin saturation of oxygen.

The right shift of the oxygen dissociation curve means that the hb saturation is decreased and the affinity of the hemoglobin to oxygen is reduced and the oxygen is released from the Hb and taken up by the cell

The main cellular parameter affecting the Oxygegn dissociation curve are

1) pH

When the pH decreases(more acidic) , the oxygen dissociation curve shift to Right

pH decreases when the concentration of the cabon dioxide increases in the blood(Bohr effect)

In systemic circulation near the tissue the concentration of the carbon dioxide is very high .Thus the affinity of hemoglobin to the oxygen is reduced and the oxygen get released from the hemoglobin and taken up by the cell

2)High level of 2,3 DPG(DIPHOSPOGLYCERATE) shift the oxygen dissociation curve to RIGHT

2,3 DPG Is produced by the erythrocyte by the process of glycolysis , it usually occur in the reduced oxygen condition. so it means that when the 2,3 DPG production is more, it menas that the oxygen content is low , and tissue get more oxygen.

Decrease in pH and the increase in 2,3 DPG help to solve the oxygen problem in the cell.Because both result in decreased affinity of hemoglobin to the oxygen. It means that the oxygen is released from the hemoglobin and available for the uptake by the cell.

Sydney Mullin answered 1 year ago

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