Question

The negative result for acetylcholine receptor antibodies rules out ____________ ___________ as a diagnosis.

please fill in the two blanks as well

Answer 1

The negative result for acetylcholine receptor antibodies rules out Myasthenia Gravis as a diagnosis.

Myasthenia gravis is a neuromuscular disease that causes varying degrees of skeletal muscle weakness. It affects Muscles of the eyes, face, and swallowing. It can also cause double vision, drooping eyelids diffiiculty in walking & Talking.

This condition occur as a defect in the transmission of nerve impulses to muscles.The communication between the nerve and muscle is interrupted at the neuromuscular junction( the place where nerve cells connect with the muscles they control)

It is an autoimmune disorder, with most of the Patients having antibodies against acetylcholine receptor (AChR antibodies) in the serum.(These Antibody Inhibits the action of Neurotransmitter Acetyl Choline,Which is responsible for communication between the nerve and muscle at Neuromuscular junction)

also, Anti-acetylcholine receptor antibodies are present in about 80%- 90% of patients with myasthenia gravis.

Hence,The negative result for acetylcholine receptor antibodies rules out Myasthenia Gravis as a diagnosis.