Question

Give 2 examples of vasculogenesis and angiogenesis methods which are currently use in clinics.DEfine methods and present advantages and disadvantages of methods in detail

Answer 1

VASCULOGENESIS :-

Vasculogenesis is the process of the blood vessel formation in the embryo , occuring by a de novo production of endothelial cells .

It is sometimes paired with angiogenesis as the first stage of the formation of the vascular network , closely followed by angiogenesis .

• Vasculogenesis occurs during embryologic development of the circulatory system . Specifically , around blood islands , which first arise in the mesoderm of the yolk sec at 3 weeks of development .
• vasculogenesis can also occur in the adult organism from circulating endothelial progenitor cells ( derivatives of stem cells ) able to contribute , albeit to varying degrees , to neovascularization .

Examples :-

• Tumor growth
• Revascularization or neovascularization after trauma , for example , after cardiac ischemia or retinal ischemia .

ANGIOGENESIS :-

Angiogensis is the physiological process through which new blood vessels form from pre-existing vessels , that formed in earlier stage of vasculogenesis .

Angiogenesis continues the growth of the vasculature by processes of sprouting and splitting .

This process is essential for healing , growth , development and maintainance .The body controls angiogenesis by balancing stimulatory and inhibitory factors .

IMPORTANCE :-

• The study of blood vessel formation is essential component of embryonic development , congenital malformations , degenerative diseases , inflammation and cancer and thus widespread appeal to the biomedical field .
• Moreover , scientists are now harnessing this information for the purpose of building living blood vessel substitutes for replacement of diseased arteries and veins .