Question

talk about differences in pharmacokinetics Discuss the differences in absorption between protein drugs and nucleic acid drugs . Provide your answer with less than 100words

Answer 1

Sex differences in metabolism (phase I and II) are believed to be the major cause of differential pharmacokinetics between men and women. Many CYP450 enzymes (phase I metabolism) show a sex-dependent difference in activity. Most of the phase II enzymes have a higher activity in men than in women.

The use of proteins as drugs is by no means new. Insulin, gamma-globulin and protein-containing vaccines have been routinely employed for decades. ... A major potential power of proteins as therapeutic agents resides in their intrinsic compatibility with living systems. Most drugs available today work by interacting with certain proteins, which are the cause of disease. However, they often have side effects, as they also interact with non-target proteins.

Nucleic acid therapeutics, based on nucleic acids or closely related chemical compounds, are an emerging new class of therapeutics for treating unmet medical needs. They are capable of targeting a disease at the genetic level by preventing the expression of disease-causing proteins

Proteins are absorbed in the form of amino acids from small intestine. The levo amino acids are actively absorbed by means of sodium cotransport, whereas, the dextro amino acids are absorbed by means of facilitated diffusion.
Absorption of amino acids is faster in duodenum and jejunum and slower in ileum.