Question

3. Explain in detail (200 words or less) how you would use the function(s) of the Core protein VII from the adenoviridae to develop or generate an antiviral therapy or treatment, describing why/how this treatment stops or limits virus lytic infection. (Note: You can not use an established antiviral therapy or treatment for your virus to answer this question.)

Answer 1

The protein VII is present packaged into the adenovirus genome and it is a histone like-proteins and this helps in protecting the viral genomes through the cellular DNA machinery which damages the viral genome. The core protein VII can be used for making antiviral therapy because this helps in repressing the viral DNA and hence prevents transcription. It can be used for preparation of antiviral injection as it helps in treating and killing the viral particles by condensing the DNA and repressing the transcription. As the protein is used in the antiviral therapy, it will lead to preventing the transcription and condense the DNA and will kill the viral particles.

This treatment limits the virus lytic infection because in this it tends to prevent the transcription of viral genome material and hence prevents it from assembly and cell lysis. Also it prevents the virus DNA from entering the lytic cycle and hence new phage production is stopped. This prevents further assembly and hence leads to killing of the viral particle.