In: Anatomy and Physiology
Specifically, what is the physiological basis behind the use of Beta 2 agonists, what are the side effects associated with its use, does it actually work, what type of athlete would benefit from its use, and is it banned in competition by the WADA and NCAA or NAIA?
Beta 2 agonists are the class of drug that acts on beta 2
adrenergic receptors present in various organs such as GIT,
bronchi, detrusor muscles of uterus and blood vessels. The beta 2
agonist causes brochodilation and is used to treat COPD and
asthma.
MECHANISM OF ACTION : The beta 2 agonists act on beta 2
adrenoreceptors in bronchi and increases cAMP production. This
results in decreased intracellular calcium and increased membrane
potassium conductance. Increased cAMP also decreases
myosin light chain kinase activity. This results in muscular
relaxation and bronchodilation in lungs improving
ventilation.
SIDE EFFECTS : anxiety, tremors, increased sweating, tachycardia,
palpitations, hypokalemia
More severe side effects include cardiac arrhythmia, myocardial
ischaemia and pulmonary edema.
Beta 2 agonists also increases blood supply to skeletal muscles
thus facilitating muscle contraction. They also increase glucose
uptake by the muscle cells. These effects increases performance in
athletes. It benefits athletes involved in endurance sports such as
cycling, swimming, marathon runners.
The world anti doping agency has prohibited its use and beta 2
agonists are banned in sports