Why do microsatellites, such as the one that causes Huntington's disease, occur in genomes? A. Microsatellites...

Why do microsatellites, such as the one that causes Huntington's disease, occur in genomes?

A. Microsatellites are caused by insertion of DNA material by viruses

B. Microsatellites are a result of very slow evolutionary processes

C. None of these

D. The body is better able to interpret microsatellite sequences into proteins, so they are more common in the genome

E. DNA polymerase "stutters" on repeated bases during DNA replication and adds or deletes bases

Expert Solution

Answer:

(E) DNA polymerase"stutters" on repeated bases during DNA replication and adds or deletes bases.

Explanation:

Microsatellites are sequence of 4-6 base pairs repeated over 50-60 times. It's not inserted by virus. There is a high rate of mutations in the Microsatellites but these are mainly intronic or non- coding regions, so it doesn't have much effect.It arises due to stuttering of the DNA polymerase while replication. This action is responsible for repetition of a base pair sequence in the genome , which is known as Microsatellites.

Give a thumbs up if you like the answer . Thank you:)

gladiator answered 2 years ago

Huntington's Disease: The role of the protein targeted by the antisense

Huntington's Disease is caused by a dominant gene. The symptoms do not appear until middle age(...

Huntington's Disease is caused by a dominant gene. The symptoms do not appear until middle age( age 40-45). There is a gradual degeneration of the nervous system which leads initially to muscle tremors. Death usually occurs within 10-15 years after the appearance of the initial symptoms due to deterioration of the nervous system. As the human genome is typed, more and more tests are available to determine if a person carries a gene like this one for which there is...

ANSWER WITH A GENERAL IDEA/MECHANISM RATIONALE Huntingtin is a disease gene linked to Huntington's disease, a...

ANSWER WITH A GENERAL IDEA/MECHANISM RATIONALE Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. How would you design a peptide that could prohibit the loss of the neurons? Describe your rational for the design of the peptide. In detail: 1. What target sequences would you need to target the peptide to the correct location in the cell. Explain your choice. 2. What other sequences would you need for the peptide...

"We now know that the core molecular cause of Parkinson's disease and Huntington's disease resembles that...

"We now know that the core molecular cause of Parkinson's disease and Huntington's disease resembles that of several other neurodegenerative disorders: Creutzfeld-Jakob disease, Alzheimer's disease, frontotemporal dementia, chronic traumatic encephalopathy (the progressive brain degeneration seen in people who have suffered repeated concussions), and the genetic form of amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease). All of these diseases result from abnormally folded proteins that form clumps in the brain, becoming toxic and eventually killing neurons. In 1982, Stanley Pruisner...

Why Next-Generation Sequencing (NGS) does not allow to detect expansion repeats disorders (e.g Huntington's disease) and...

Why Next-Generation Sequencing (NGS) does not allow to detect expansion repeats disorders (e.g Huntington's disease) and what would a diagram of the coverage of the region for Huntington's disease look like in a coverage plot (e.g Increased/decreased)?

a) Why do increasing returns to scale occur? b)why do decreasing returns to scale occur?

described a method of evaluation of patient learning appropriate for Huntington's disease and stages of development

Huntington's Disease is caused by an autosomal dominant allele. Suppose a prospective father is diagnosed with...

Huntington's Disease is caused by an autosomal dominant allele. Suppose a prospective father is diagnosed with this disease. His own mother also had it, but not his father. The prospective mother has no family history of the disease. a. What are the genotypes of these two prospective parents? (Tell how many copies of the dominant Huntington's allele the man and the woman each has.) b. What is the probability that a child of theirs would inherit the disease? Explain.

You encounter a client, 32 y.o., with an early diagnosis of Huntington's Disease. What are some...

You encounter a client, 32 y.o., with an early diagnosis of Huntington's Disease. What are some pressing issues and suggested services? Is an employment goal feasible or do you need to concentrate only on Independent Living needs? What about services for his family or support system?\

What types of genomes do viruses have

Question