1. Select all of the events below which would reverse ER stress caused by unfolded protein:...

1. Select all of the events below which would reverse ER stress caused by unfolded protein:

a) increase in spliced Hac-1 mRNA

b) transcription of chaperones

c) transcription of the gene encoding p97

d) transcription of lipid synthesis genes

2. Select all of the enzymes below whose activity helps to give a protein more time to fold:

a) glucosyltransferase

b) alpha-mannosidase

c) Glucosidase I

d) Glucosidase II

Solutions

Expert Solution

ANS1. Transcription of chaperon

The unfolded protein response (UPR) is a cellular stress response related to the endoplasmic reticulum (ER) stress. The UPR is activated in response to an accumulation of unfolded or misfolded proteins in the lumen of the endoplasmic reticulum.

ANS 2. Glucosidase -II

Folding enzymes catalyze disulfide bond formation or proline cis–trans. The N- and H-domains help to position the peptide in a looped orientation during. trimming by glucosidase II of the diglucosylated protein to the eventual unglucosylated. fail to analyze at such long chase times because cell proliferation is faster.

gladiator answered 1 year ago

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