Explain the general mechanism for the simultaneous transport of Na+ and K+ by the Na+/K+ ATPase...

Explain the general mechanism for the simultaneous transport of Na+ and K+ by the Na+/K+ ATPase (aka. Na+/K+ pump) describing:

The result of this transport on the concentrations of Na+ and K+ inside and outside of the cell

How the binding of Na+ and K+ are related to the conformation changes on the protein

We discussed F-type pumps, which can also function in the reverse direction (i.e. ATP synthase). Explain how this protein can function both as a pump and as a "channel-like protein" (although the mechanism of proton transport is not the same as a typical channel) depending on the direction in which protons move (down or against their free energy gradient). How is ATP hydrolysis or synthesis associated to the movement of protons in each case?

Explain why the cystic fibrosis conductance regulator (CFTR) does not function as a pump even though it is a member of the ABC transporter family (what type of protein does CFTR behave like?)

Expert Solution

gladiator answered 1 year ago

Explain why the (Na+-K+)-ATPase carries out transport in one direction only.

A neuron is poisoned with a chemical, which is an inhibitor of the Na+-K+ ATPase. Explain...

A neuron is poisoned with a chemical, which is an inhibitor of the Na+-K+ ATPase. Explain what would happen to the resting membrane potential (RMP) of the cell (will it depolarize, hyperpolarize or remain the same). In your answer, a.)identify the three factors that determine RMP in a neuron, b.) identify whether each factor causes membrane potential to be more or less negative, and c.) explain whether or not the chemical would affect each factor.

Consider the Na+/K+-ATPase to be present in a membrane with the following conditions: Na+ concentration inside,...

Consider the Na+/K+-ATPase to be present in a membrane with the following conditions: Na+ concentration inside, 50mM, outside, 250mM; K+ concentration inside, 70mM, outside, 5 mM; at 298K with the voltage being 50mV lower in the interior. 3Na+(in) + 2K+(out) + ATP + H2O ↔ 3Na+(out) + 2K+(in) + ADP + Pi Calculate the free-energy difference for moving both Na+ and K+ in the observed stoichiometry. A -12 KJ/mol B 12 KJ/mol C 24 kJ/mol D 31 kJ/mol

Primary Active Transporter Na+/K+ ATPase pump. Describe how this pump maintains Na+ and K+ ionic gradients...

Primary Active Transporter Na+/K+ ATPase pump. Describe how this pump maintains Na+ and K+ ionic gradients across the cell membrane. SECONDARY ACTIVE TRANSPORTERS: How do these secondary transporters benefit from the ionic gradients created by primary active transporters? What is the difference between cotransport/countertransport? (Please don't write the answer on a separate page all over the place. I'm new to A&P 1 and I'm still learning, so I need to be explained, rather than shown notes like what I take...

Explain the mechanism of transport of oxygen by blood. And explain the mechanism of transport of...

Explain the mechanism of transport of oxygen by blood. And explain the mechanism of transport of carbon dioxide by bood

True or False? Movement of Na+and K+through a Na+/K+–pump is a facilitated transport across a membrane...

True or False? Movement of Na+and K+through a Na+/K+–pump is a facilitated transport across a membrane Movement of Na+and K+through a Na+/K+–transporter is an electrogenic antiporter process Movement of Na+and K+through a Na+/K+–transporter is an active transport across a membrane

Cholera toxin inhibits the Na+/K+ATPase activity of intestinal epithelial cells. Resulting with decreased uptake of glucose....

Cholera toxin inhibits the Na+/K+ATPase activity of intestinal epithelial cells. Resulting with decreased uptake of glucose. Describe why inhibiting the Na/K+ ATPase pump affects glucose uptake in the intestine.

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Explain the general mechanism for the simultaneous transport of Na+ and K+ by the Na+/K+ ATPase...

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