Explain the general mechanism for the simultaneous transport of Na+ and K+ by the Na+/K+ ATPase...

Explain the general mechanism for the simultaneous transport of Na+ and K+ by the Na+/K+ ATPase (aka. Na+/K+ pump) describing:

The result of this transport on the concentrations of Na+ and K+ inside and outside of the cell

How the binding of Na+ and K+ are related to the conformation changes on the protein

We discussed F-type pumps, which can also function in the reverse direction (i.e. ATP synthase). Explain how this protein can function both as a pump and as a "channel-like protein" (although the mechanism of proton transport is not the same as a typical channel) depending on the direction in which protons move (down or against their free energy gradient). How is ATP hydrolysis or synthesis associated to the movement of protons in each case?

Explain why the cystic fibrosis conductance regulator (CFTR) does not function as a pump even though it is a member of the ABC transporter family (what type of protein does CFTR behave like?)

Solutions

Expert Solution

gladiator answered 1 year ago

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