9) Why are developing B cells so much more likely to successfully recombine L chain genes...

9) Why are developing B cells so much more likely to successfully recombine L chain genes than H chain genes?

Expert Solution

In heavy chain , V, D and J segments are join to each other whereas in light chain, only V and J segments are joined.

In heavy chain, D and J segments are joined firstly in pre pro B cell by CXCL12 response of stromal cell. Then V and DJ segments are joined in por B cell by IL-7 response of stromal cell. So heavy chain rearrangement needs two steps in B cell development.

But in light chain, V and J segments are joined in pre B cell. Surrogate L chain is formed firstly and then actual light chain ultimately formed in same pre B cell. So it needs only one step of B cell development .

For this reason L chain is successfully recombine than H chain .

gladiator answered 2 years ago

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