Question

In: Statistics and Probability

I am particularly confused regarding the number of degrees of freedom that should be used in...

I am particularly confused regarding the number of degrees of freedom that should be used in conducting the t-tests for the intercept and slope coefficients, and 95% associated confidence intervals.

We are testing means (there are 6) so should there be t 4 degrees of freedom, level of significance 0.05

Is there any good explanations on the relationship between ANOVA and regression models. Are they the same?

The data shown below are the 24-hour dissolution percentage results for a drug product, tested in a dissolution apparatus.

Month 0 3 6 9 12 18
1st sample 81.92 82.39 75.32 68.85 74.19 62.87
2nd sample 81.76 82.78 78.05 76.60 77.87 56.05
3rd sample 76.22 70.33 80.02 71.50 64.06 54.20
4th sample 78.95 90.10 66.69 71.68 70.13 57.72
5th sample 80.05 79.23 79.00 68.23 69.45 50.90
6th sample 90.55 77.04 78.00 65.05 70.82 62.23
sample mean 81.58 80.31 76.18 70.32 71.09 57.5
standard deviation 4.87 6.60 4.91 3.92 4.66 4.86

The data came from a stability monitoring programme: the drugs were stored at 25 degrees C and 60% relative humidity and were measured at 6 different time points or months.

The mean of all the 36 values is 72.83

The total sum of squares is 3089.667

For hypothesis testing, set the significance level to 0.05

(a) To test the hypothesis that the "drug's mean dissolution rates at different time points are the same", we can fit a linear regression model to the data

dissolution = Bo +B1 * month

The estimates of the coefficients are below, along with their standard errors.

Coefficients:

Estimated Standard Error

Intercept: 83.3765 1.4413

Month -1.3186 0.1449

(i) Conduct tests on the hypothesis that:

Ho: Bo = 100

Ho: Bo = 0

(ii) What information do we want to get about the drug by testing:

Ho: Bo = 100

Ho: Bo is not equal to 0

(iii) Conduct 95% confidence intervals for Bo and B1

Based on the confidence intervals, will we reject the above two hypotheses or not? Why?

We then conduct an ANOVA test for the regression model.

The following table shows the regression sum of squares and residual sum of squares

Response: Dissolution
DF Sum of Squares Mean Squares F-Value
Regression 2190.73
Residual 898.94

(iv) Explain how the regression sum of squares and residual sum of squares are calculated

(v) Calculate the 5 values, two mean square values, and the F-value

What is the null hypothesis for the F-test?

Another way to test the hypothesis that the drug's mean dissolution rates at different time points are the same is to conduct an ANOVA test

(i) Assume the hypothesis Ho: B1=0 is true, should we reject or not reject the hypothesis in the ANOVA test?

(ii) Assume the hypothesis Ho: B1=0 is false, should we reject or not reject the hypothesis in the ANOVA test?

Conduct an ANOVA test on the hypothesis that the drug's mean dissolution rates at different time points are the same?

Solutions

Expert Solution

(i) and (ii)

Ho: Bo = 100

Ho: Bo is not equal to 100

Value of t test= (83.3765-100) / 1.4413 =-11.5337

p-value=2P(t>11.5337|t~t34)=0.0000<0.05

So we reject H0 at 5% level of significance and hence y-intercept is significantly different from 100.

(iii) 95% C.I. for Bo is

(83.3765-t0.025,34 *1.4413, 83.3765+t0.025,34 *1.4413)=(80.4475, 86.3055)

where t0.025,34=2.0322

95% C.I. for B1 is

( -1.3186 -t0.025,34 * 0.1449, -1.3186 +t0.025,34 * 0.1449)=(-1.6131, -1.0241)

(iv) Regression sum of squares=SSR=dfregdfMSR ; MSR=mean sum of squares due to regression

=1* 2190.73 = 2190.73

Residual (Error) sum of squares=SSE=dferror MSE ; MSE=mean sum of squares due to error

=34* 898.94 =30563.96

(v)

Response: Dissolution
DF Sum of Squares Mean Squares F-Value
Regression 1 2190.73 2190.73 2190.73/898.94=2.4370
Residual 34 30563.96 898.94

Null hypothesis, H0: regression equation is insignificant i.e. B1=0 vs. Alternative hypothesis, H1: regression equation is significant i.e. B1 is different from zero.

p-value=P(F>2.4370|F~F1,34)=0.1278>0.05 so we fail to reject H0 at 5% level of significance.


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