Suppose you were planning to use liposomes in an attempt to deliver a drug that could...

Suppose you were planning to use liposomes in an attempt to deliver a drug that could potentially be used in the treatment of a tumor whose cells have a protein called tumor cell antigen (TGA) in their membrane. This protein found in the membrane of tumor cells has been shown to be absent in all normal cells. A.) How would you need to construct your liposome to protect it from the host immune system phagocytes? B.) How might your liposome be construct to increase its target specificity to the tumor cell only?

Solutions

Expert Solution

Drug delivery using liposomes has been a valuable strategy to mitigate toxicity of anticancer drugs in patients. While this approach has not significantly improved clinical efficacy till now, yet new understanding of the mechanisms of interactions between liposomes and the immune system will build up the the foundations for future work that will realize the full clinical potential of cancer medicinal treatment.

gladiator answered 1 year ago

Next > < Previous

Related Solutions

If a nation were to attempt to restimulate its economy, would you advise the use of...

If a nation were to attempt to restimulate its economy, would you advise the use of Monetary or Fiscal Policy to do so? Why? What are the strengths of each? What are the drawbacks of each?

Could you explain these: 2. Which piece of laboratory equipment should be used to deliver a...

Could you explain these: 2. Which piece of laboratory equipment should be used to deliver a 10.00 mL sample of acid from a stock container to a flask for a titration? (A) 1.0 mL Beral pipet used 10 times (B) 10 mL graduated cylinder (C) 10 mL volumetric pipet (D) 25 mL beaker 2) C For this one, in general what do you use all the options for? There was another question like this in which the answer was to...

Drug regulations were created to _______ the public from drug miss use. The regulatory agency responsible...

Drug regulations were created to _______ the public from drug miss use. The regulatory agency responsible for ensuring that drugs and medical devices are safe and effective is the_______and ___________________ What is a black box warning? Therapeutic drugs and biologic are reviewed in for phrases. List and briefly describe each: It costs approximately 2.5 billion in ________and_______Expenses to bring a new drug to market. It takes approximately _______ years to R and D to bring a truck to FDA for...

Imagine you were called in by the government to advice on whether it should attempt to...

Imagine you were called in by the government to advice on whether it should attempt to prevent cyclical fluctuations by the use of fiscal policy. What advices would you give and how would you justify the advices? (Answer in depth) *600 words

Drug G comes from the pharmacy as 40mg/5cc. How many milliliters will you give to deliver...

Drug G comes from the pharmacy as 40mg/5cc. How many milliliters will you give to deliver 12 mg of drug? Dopamine comes prepared as 400mg in 250 ml D5W bags (1600 mcg/ml). You have been ordered to deliver 20 mcg/kg/min to a hypotensive ICU patient who weighs 76 kg (167.2 lbs). You use IV tubing with a drip factor of 60, meaning every 60 drops is equal to 1 milliliter (60 gtts/ml). How many drops per minute will you deliver...

Describe how you could use pH control to separate lead and iron if they were both...

Describe how you could use pH control to separate lead and iron if they were both precipitated as their hydroxides. (Hint: how could pH be used to dissolve one of the hydroxide precipitates but not the other?)

You want to use retroviruses to deliver DNA to a type of cells to promote certain...

You want to use retroviruses to deliver DNA to a type of cells to promote certain phenotype. Before you start, you want to estimate the delivery efficiency. The cells are spread on a solid support and covered with an aqueous medium. The culture dish is 6 cm in diameter and the medium is 6 mm deep. You add the virus particle at the top of the medium. The virus has a half life of 8 hours in solution. The diffusion...

How could you use play in light of Vygotsky’s sociocultural theory? How could you use play...

How could you use play in light of Vygotsky’s sociocultural theory? How could you use play in light of Piaget’s four stages of cognitive development theory?

Do you think the Rockerfeller drug laws were effective in reducing drug offenses in New York?...

Do you think the Rockerfeller drug laws were effective in reducing drug offenses in New York? Do you believe they should have been repealed? Why or why not?

1) What were the primary standards used for each standardization? Could you use them interchangeably? Why...

1) What were the primary standards used for each standardization? Could you use them interchangeably? Why should we pay attention to the mass of the primary standard in the standardization of NaOH and HCl? 2) Why do we boil and then cool the distilled water before preparation of NaOH? Why this process is not necessary for the preparation of HCl? 3) In the titration of weak acid with a strong base why did you use phenolphthalein as indicator? 4) For...

Subjects