Histidine has ionizable groups with pKa values of 1.8, 6.0, and 9.2, as shown below. A...

Histidine has ionizable groups with pKa values of 1.8, 6.0, and 9.2, as shown below. A biochemist makes up 100 mL of a 0.100 M solution of histidine at a pH of 5.40. She then adds 40 mL of 0.10 M HCl. What is the pH of the resulting solution?

The book answer is 2.4. Please show work to help me understand how they arrived at this.

Expert Solution

queen_honey_blossom answered 1 year ago

A nonstandard amino acid has three ionizable groups, with pKa values of 2.6, 7.4, and 10.13....

A nonstandard amino acid has three ionizable groups, with pKa values of 2.6, 7.4, and 10.13. A 0.1 M solution of this amino acid is made, 100 ml total, at pH 2.6. To this solution is added 10 ml of 1 M NaOH. What is the final pH of this solution after the addition? A) 3.2 B) 8.0 C) 7.4 D) 6.8 E) 10.13

Indicate how the pKa of the ionizable group of histidine would be changed in a nonpolar...

Indicate how the pKa of the ionizable group of histidine would be changed in a nonpolar pocket (increase/decrease) PLEASE EXPLAIN WHY. I thought it would increase but that's not correct

A molecule has an ionizable group with a pKa value of 8. At pH equal to...

A molecule has an ionizable group with a pKa value of 8. At pH equal to 7.0, estimate roughly how much of the group is deprotonated (expressed as %)? Use 2 decimal points. Do not use scientific notation to enter your answer.

All amino acids have two ionizable functional groups: an α-amino group (average pKa of 9.4) and...

All amino acids have two ionizable functional groups: an α-amino group (average pKa of 9.4) and an α-carboxylic acid group (average pKa of 2.2). Arginine also has an ionizable side chain (R group) with a pKa of ~12.5. One of the possible ionization states of arginine is shown below. At what pH would the above structure be the predominant ionization state? Note: Consider the ionization state of all three of the functional groups. The protonated form of the R group...

Selenocysteine has pKa values for the a-amino, a-carboxyl, and sidechain groups of 10.0, 1.90, and 5.4,...

Selenocysteine has pKa values for the a-amino, a-carboxyl, and sidechain groups of 10.0, 1.90, and 5.4, respectively. the sidechain looks just like cysteine, but has a selenium in place of the sulfur. In terms of protonation and charge, selenium behaves like oxygen or sulfur. Answer the following. 1) what is the overall charge of selenocysteine at pH 6.2?

The equilibrium constant, K, for the reaction shown below has a value 1.8 x 105. In...

The equilibrium constant, K, for the reaction shown below has a value 1.8 x 105. In this reaction which is the strongest acid and which is the strongest base? CH3CO2H(aq) + H2O (l) --->H3O+(aq) + CH3CO2-(aq) please explain why?

For the registers values shown below, what are the values of $t2 & $t3, for the...

For the registers values shown below, what are the values of $t2 & $t3, for the following sequence of instructions? $s0=0xFFFF0011 $s1=0x00002136 sll $t2, $s0, 2 and $t3, $t2, $s1

The values of y and their corresponding values of y are shown in the table below...

The values of y and their corresponding values of y are shown in the table below x 2 3 4 4 6 y 2 3 5 4 6 A) Calculate the coefficient of correlation; B) Calculate the coefficient of determination; C) Obtain the regression coefficients and write the regression expression; D) Provide your prediction of the dependent variable if the value of the independent variable is 4.

The amino acid leucine has two titratable groups, the α-amino, pKa 9.6 and the α-carboxyl, pKa...

The amino acid leucine has two titratable groups, the α-amino, pKa 9.6 and the α-carboxyl, pKa 2.4. Calculate the ratio of acidic and basic forms and express them as [A]/[HA] ratio or [B]/[BH] of the titrating group at the following pH values: α-carboxyl @ 1.4, 1.9, 2.4, 2.9, 3.4; α-amino @ 8.1, 8.6, 9.1, 9.6, 10.1. Plot pH vs. [B]/[BH] for each group, on the same graph. Compare similarities or disparities in the titration of each group.

Reaction 1: NH4+(aq) + H2O(l)NH3 + H3O+(aq) pKA = 9.2 the system described above, it has...

Reaction 1: NH4+(aq) + H2O(l)NH3 + H3O+(aq) pKA = 9.2 the system described above, it has been found that the activity coefficients for the species in solution are: (NH4+) = 0.80, (H3O+) = 0.90, (OH-) = 0.88 – the activity coefficients for neutral molecules are 1.0. a.) Write down the equilibrium expression for Reaction 1 in terms of activity coefficients and concentrations – i.e. the correct equilibrium expression which is NOT just in terms of concentrations. b.) Now algebraically manipulate...

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