Question

⦁   Discuss the role of calcitonin in maintaining normal blood calcium concentration.

Answer 1

Ans. Calcitonin is involved in helping to regulate level of calcium and phosphate in the blood , opposing the action of parathyroid hormone . This means it acts to reduce calcium level in the blood.

Calcitonin is a hormone that is produced and released by C-cells (parafollicular cell) of thyroid gland. Iit reduce calcium level in the blood by two main mechanism .

A. It inhibits the activity of osteoclasts,which are the cells responsible for breaking down bone. Therefore , the inhibition of osteoclasts by calcitonin directly reduces the amount of calcium release into the blood.

B. It can also decrease the reabsorption of calcium in the kidney,again leading to lower blood calcium level .

When level of calcium in blood increase calcitonin is secreted in higher quantity & when decrese , calcitonin release decrease too. The secretion of calcitonin is inhibited by somatostatin ,which also be released by c- cells of thyroid gland.

Calcium homeostasis ::::

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