Question

1. Describe the three important mechanisms for returning blood back to the heart during exercise.

- respiratory pump

- muscle pump

- valves in the veins

Answer 1

RESPIRATORY PUMP-

• Respiratory activity influences venous return to the heart. Briefly increasing the rate and depth of respiration promotes venous return and therefore enhances cardiac output.

• Respiratory activity affects venous return through changes in right atrial pressure, which is an important component of the pressure gradient for venous return.

• Increasing right atrial pressure impedes venous return, while lowering this pressure facilitates venous return. Respiratory activity can also affect the diameter of the thoracic vena cava and cardiac chambers, which either directly (e.g., vena cava compression) or indirectly (by changing cardiac preload) affect venous return.

• Pressures in the right atrium and thoracic vena cava are very dependent on intrapleural pressure (Ppl ), which is the pressure within the thoracic space between the organs (lungs, heart, vena cava) and the chest wall.

• During inspiration, the chest wall expands and the diaphragm descends. This makes the Ppl become more negative, which leads to expansion of the lungs, cardiac chambers (right atrium and right ventricle), and the thoracic superior and inferior vena cava. This expansion causes the intravascular and intracardiac pressures (e.g., right atrial pressure) to fall.

• Because the pressure inside the cardiac chambers falls less than the Ppl, the transmural pressure (pressure inside the heart chamber minus the Ppl) increases, which leads to cardiac chamber expansion and an increase in cardiac preload and stroke volume through the Frank-Starling mechanism.

• Furthermore, as right atrial pressure falls during inspiration, the pressure gradient for venous return to the right ventricle increases.

• During expiration, the opposite occurs although the dynamics are such that the net effect of respiration is that increasing the rate and depth of ventilation facilitates venous return and ventricular stroke volume.

• The left side of the heart responds differently to the respiratory cycle. During inspiration, expansion of the lungs and pulmonary tissues causes pulmonary blood volume to increase, which transiently decreases the flow of blood from the lungs to the left atrium. Therefore, left ventricular filling actually decreases during inspiration. In contrast, during expiration, lung deflation causes flow to increase from the lungs to the left atrium, which increases left ventricular filling. The net effect of increased rate and depth of respiration, however, is an increase in left ventricular stroke volume and cardiac output.

MUSCLE PUMP AND VALVES IN THE VEINS-

• A major mechanism promoting venous return during normal locomotory activity (e.g., walking, running) is the muscle pump system.

• Peripheral veins, particularly in the legs and arms, have one-way valves that direct flow away from the limb and toward the heart.

• Veins physically located within large muscle groups undergo compression as the muscles surrounding them contract, and they become decompressed as the muscles relax. Therefore, with normal cycles of contraction and relaxation, the veins are alternately compressed and decompressed (i.e., "pumped").

• muscle contraction propels blood forward through the open distal valves (upper valves of veins) and impedes flow into the muscle as the proximal valves close during contraction (lower valves of veins).

• During muscle relaxation, the proximal valves open and blood flows into and fills the venous segment.

• Initially during relaxation, the distal valves close, but then they open as the volume of blood and pressure increases in the venous segment.

• The net effect is that the cycle of compression and relaxation propels the blood in the direction of the heart. Venous valves prevent the blood from flowing backwards, thereby permitting unidirectional flow that enhances venous return.

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