what are N-Cadhering and Cadherin 9 ? What they have in common and where is most...

what are N-Cadhering and Cadherin 9 ?
What they have in common and where is most expressed in the mouse brain.

Expert Solution

Cadherins (Calcium-dependent ones) are a type of cell adhesion molecules (CAM) that mainly function in the formation of adherens junction to bind cells.

Cadherins are usually named according to their tissue distribution in the body. N-cadherins are named so because they are mostly distributed in neurons.

Cadherin 9 is a type II classical cadherin. It is an integral membrane protein and it mediates calcium-dependent cell-cell adhesion.

Gene expression profiles indicate that Cadherin 9 expression is important for synaptogenic specificity. Cadherin 9 expression is high in neurons of brain, and its downregulation can lead to a selective decrease in the size and number of hippocampal dentate gyrus (DG) neurons.

gladiator answered 2 years ago

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