Question

How many tablets and volume of indicated diluent (denoted by Xs below) is required to make the following compounded product?

Drug Formulation: ACETAZOLAMIDE SUSPENSION 25 MG/ML

Acetazolamide 250 mg tablets X tablets needed

Ora-Sweet:Ora-Plus qsad 240 mL

X mL Ora-Sweet needed

Answer 1

GENERIC NAME : Acetazolamide

INDICATION : Reduction of intra-ocular pressure in open-angle glaucoma, secondary glaucoma and peri-operatively in angle-closure glaucoma

DOSAGE FORM : Suspension

STRENGTH : 25mg/mL

STABILITY : 60 days

STORAGE : Refrigerate (preferable) or at room temperature.

Ingredient

Acetazolamide                                                250                  12 tablets

Vehicle                                                qs                     240 ml

Ora-Sweet:Ora-Plus qsad 240 mL

240 mL Ora-Sweet needed i.e. (1:1)

PROCEDURE:

1. Crush tablets in a mortar to a fine powder.

2. Levigate the powder with small amount of vehicle until a smooth paste is formed.

3. Add more vehicle to the paste until a liquid is formed and transfer the liquid into the container.

4. Use additional vehicle to rinse the remaining drug from the mortar and pour into the container.

5. Make up to final volume with vehicle.

6. Shake well and label.