Question

3. In mice, genes for albinism (a), chronic inflammation (i), and reduced sense of smell (r) are linked.  You initially crossed a mouse that is homozygous dominant for all three traits with a mouse that is homozygous recessive for all three traits.  You then crossed several of the resulting F₁ offspring to mice that are homozygous recessive for all three traits.  You observe the following phenotypes in the offspring:

colored, healthy, normal smell sense	41
albino, chronically inflamed, reduced smell sense	45
colored, chronically inflamed, reduced smell sense	11
albino, healthy, normal smell sense	12
colored, healthy, reduced smell sense	2
albino, chronically inflamed, normal smell sense	3
colored, chronically inflamed, normal smell sense	14
albino, healthy, reduced smell sense	16

a. (3 points) Diagram a map between these three genes and calculate the map distances between the genes.

b. (3 points) Calculate the coefficient of coincidence and the interference values for double crossovers amongst these genes.

c. (2 points) Using the interference value calculated in part (b), how many double recombinant F₂ progeny will you observe if you continue to breed your F₁ mice until you have 200 total offspring?

d. (2 points) If a fourth gene (z) exhibits 50% recombination with gene i, 36% recombination with gene a and 50% recombination with gene r, is this gene on the same chromosome or a separate chromosome?  If gene z is on the same chromosome as the other three genes, indicate its location by copying and modifying your genetic map from part (a).

Please for part c and d explain it with detail because i have more problem with part c and d , thank you

Answer 1

Handwritten explanation is given below for all the questions: