In the KEGG database, the pathway map for glycolysis/gluconeogenesis indicates that ___ unique enzyme/s can catalyze...

In the KEGG database, the pathway map for glycolysis/gluconeogenesis indicates that ___ unique enzyme/s can catalyze the conversion of ?-D-glucose to ?-D-glucose-6-phosphate (?-D-glucose-6P).

Solutions

Expert Solution

Option 'c' is the correct answer.

There are 4 unique enzymes that can catalyze the conversion of a-D-Glucose to a-D-Glucose-6-Phosphate. This is the first step in glycolysis and requires ATP. In mammals, there are four isozymes of hexokinase: types I, II, III and IV.(glucokinase). These isozymes differ in their catalysis, localisation and regulation. It is thought that type I hexokinase may have a catabolic function, producing G6P for energy production in glycolysis, whereas types II and III may have an anabolic function, providing G6P for glycogen or lipid synthesis. Type I hexokinase binds to the mitochondrial membrane, thereby enabling the coordination of the rate of glycolysis with that of the TCA cycle. Type IV hexokinase (glucokinase) is a liver/pancreatic b-cell enzyme that is specific for a-D-glucose, and whose level is controlled by insulin, not G6P.

gladiator answered 1 year ago

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