Question

1. Select the accurate statement that describes the benefit of long-term therapy for Tuberculosis (TB)?
A) It eradicates tubercle bacilli and provides a cure for the infection

B) It decreases drug toxicity and better patient tolerance

C) It decreases the likelihood of active infection in latent TB

2. Your patient is on metformin, glipizide, and pioglitazone for his DM II. His last 3 morning FBG are < 60mg/dl, which medication should be discontinued to avoid the risk of hypoglycemia?

A) Metformin

B) Pioglitazone

C) Glipizide

3. All of the followings accurately describes prochlorperazine (Compazine), EXCEPT:

A) It blocks acetylcholine receptors in chemoreceptor trigger zone

B) Can be co-administer with morphine to prevent nausea

C) It is indicated for nausea associated with opioids or anesthesia

4. A patient ℅ tinnitus after starting many new medications. Which of the following is most likely the cause of this ototoxicity effect?

A) Ondansetron (zofran)

B) Metformin

C) Pantoprazole

Gentamycin

Answer 1

Answer 1 : A) It eradicates tubercle bacilli and provides a cure for the infection.

They show bactericidal action rapidly , reducing bacillary load in the patient and achieve quick sputum negativity.

Answer 2 : C) Glipizide

Glipizide bind to sulfonylurea receptor SUR 1 present on the pancreatic beta cell membrane and causes brisk release of insulin. Insulin release occurs even at low-glucose concentration leading to production of severe and unpredictable hypoglycaemia.

Metformin and Pioglitazone cause little or no hypoglycemia.

Answer 3 : A) It blocks acetylcholine receptors in chemoreceptor trigger zone.

Pochlorperazine is a Dopaminergic receptor blocker ie, D2 blocking phenothiazine.

It is a labyrinthine suppressant that has selective antivertigo and antiemetic actions.

Answer 4 : D) Gentamycin

When the trough level of Gentamicin is above 2 mcg/ml , vestibular damage occurs.

The vestibular or cochlear sensory cells and hairs undergo concentration dependent destructive changes.