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In: Biology

Suppose that the researchers discovered that OFC and DLPFC patients have comparable P3 responses. First describe...

Suppose that the researchers discovered that OFC and DLPFC patients have comparable P3 responses. First describe the pattern of results that Dynamic filtering theory would normally predict in this experiment, and then explain whether these hypothetical results would fit with that prediction. (neuroscience class qn)

Solutions

Expert Solution

OFC- orbitofrontal cortex.

DLPFC - Dorsolateral prefrontal cortex.

Thompson-Schill et al. (1997) wanted to study the dynamic filtering hypothesis so they had subjects generate verbs associated with presented nouns. It was the important experiment in the field of neuroscience and successful too. For a instance, In other words, if the person saw a “cat” they might say “meow” or “nap” or something else. Thompson-Schill et al. assigned subjects to a high or low noun-verb selection condition. In the high condition, subjects were shown nouns with many associated verbs (e.g., a ball is shown and subject could produce “bounce,” “hit,” “kick,” or “throw”) whereas in the low condition subjects are shown a noun with only one (in most cases) related verb (e.g., a chair is shown and subject says “sit”).

The results of that experiment were pleasant and gave good results to his research.

They conducted this experiment to see if the inferior frontal cortex is associated with just semantic memory (basically long-term-memory-type information) or if it an area that supports working memory processes (retrieving information from semantic memory and working with it—in this case filtering through it for relevant associations). The experimenters found that the inferior frontal cortex (IFC) was more activated in the high-selection conditions than in the low-selection condition. If it had not been more activated then it would merely have been a semantic, long term, memory-related area. Because of the higher activation it was concluded that the IFC was associated with working memory, specifically pulling relevant information from semantic memory. It acts as a filtering mechanism, a dynamic filter.

The other hypothetical result were also predict by Thompson and that are as follows:-

1-)To confirm this finding Thompson-Schill et al. (1998) conducted another study with brain-damaged patients. They selected subjects with lesions of the IFC. They found that in the high-selection condition these patients failed to produce any verbs 15% of the time. But in the low-selection condition these lesioned subjects performed the same as control subjects. The researchers concluded that because those with IFC lesions could not generate verbs to go along with displayed nouns when there were possibly many to choose between, the lesion caused a deficit in selection. It was not a semantic deficit, but a working memory one. It was the first hypothetical result after done of dynamic filtering theory and got successful results too.

2)-Thompson-Schill et al. (1999) also conducted another study where they looked at the temporal lobe in addition to the IFC. The temporal lobe plays an important role in the field of neurosciences because this lovbe relates with auditory perception. It receives sensory information from years and convert it into meaningful voice and speech which is an important part of human life. The pathology related with temporal lobe is temporal lobe epilepsy.They replicated their previous experiment with one key difference. They had the subjects complete two generative trials (one of naming an action verb like in previous experiments and the other was naming an associated color) with the same list of nouns shown the second time for the subjects. Some repeated the first association task and others did the color one the second time. They found that IFC activation increased when the association task changed but temporal lobe activation decreased the second trial for both association conditions.

It was the successful experiment and useful theory given by scientist Thompson in neuroscience.


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