In: Biology
In mice the loci for tail length, fur color and whisker shape are found on the same chromosome. Long tails (T) are dominant to short tails (t), brown fur (B) is dominant to white fur (b) and straight whisker (S) are dominant to curled whiskers (s). Mice that were homozygous dominant for all three characters were crossed with mice homozygous recessive for all three characters and all of the offspring had long tails, brown fur and straight whiskers. These F1 mice were test crossed. The phenotypes of the offspring from these crosses are shown in the following table.
Tail phenotype | Fur phenotype | whisker phenotype | number of progeny |
short | brown | straight | 13 |
long | white | straight | 19 |
short | white | straight | 6 |
long | brown | straight | 43 |
short | brown | curled | 22 |
long | white | curled | 15 |
short | white | curled | 46 |
long | brown | curled | 5 |
a. Use the information in this table to construct a genetic map. Include the distances between the loci on your map.
b. For the data in this table calculate the interference. What does this value mean?
Ans:
The genotypes which found most frequently are called parental genotypes. So, genotypes T (long tail) B (brown) S (straight) and t (short tail) b (white) s (curled) are the parental genotypes. The genotypes which found less frequently is called double crossover phenotypes. So, genotypes T B s and t b S are the double crossover genotypes.
a. The genetic map is T-23.08 m.u.-S-30.76 m.u.-B.
b. The calculated interference is 0.06. This value means partial interference. The formation of one chiasma partially reduces the probability of another chiasma formation.
All the calculation given below-