Question

A 51-year-old man has suffered a myocardial infarction (heart attack). In the intensive care unit, he is started on the -adrenoreceptor blocker, metoprolol. , what is the effect of blocking this type of receptor as it relates to G-protein signaling at the molecular level?

Answer 1

what is the effect of blocking this type of receptor as it relates to G-protein signaling at the molecular level?

G protein-coupled receptors (GPCRs) are a truly ubiquitous category of membrane-bound receptors, which functionally couple hormone or neurotransmitter indicators to physiological responses. Dysregulation of GPCR signaling contributes to the pathophysiology of a host of cardiovascular disorders. Pharmacological sellers targeting GPCRs have been hooked up as therapeutic preferences for decades. Nevertheless, the power burden of cardiovascular ailments necessitates extended treatments. To that end, thrilling drug development efforts have begun to center of attention on novel compounds that discriminately set off particular GPCR signaling pathways.

Beta blockers are competitive antagonists that block the receptor websites for the endogenous catecholamines epinephrine (adrenaline) and norepinephrine (noradrenaline) on adrenergic beta receptors, of the sympathetic anxious system, which mediates the fight-or-flight response. Some block activation of all kinds of β-adrenergic receptors and others are selective for one of the three regarded kinds of beta receptors, distinct β1, β2 and β3 receptors.β1-adrenergic receptors are positioned mostly in the coronary heart and in the kidneys.β2-adrenergic receptors are positioned primarily in the lungs, gastrointestinal tract, liver, uterus, vascular smooth muscle, and skeletal muscle. β3-adrenergic receptors are positioned in fats cells.

Beta receptors are determined on cells of the heart muscles, smooth muscles, airways, arteries, kidneys, and other tissues that are section of the sympathetic nervous system and lead to stress responses, specifically when they are inspired by epinephrine (adrenaline). Beta blockers intervene with the binding to the receptor of epinephrine and other stress hormones, and weaken the outcomes of stress hormones.