Discuss the significance of haemoglobin and other red blood cell parameters in the evaluation of Anaemia.

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Discuss the significance of haemoglobin and other red blood cell parameters in the evaluation of Anaemia ?

ANAEMIA

Decrease in the number of red blood cells and decreased oxygen carrying capacity of blood. It is the lack of enough healthy red blood cells to carry adequate oxygen to your body's tissues. According to world health organization anemia is a condition in which number of red blood cells is insuffiecnt to meet the body's physiologic needs.

Normal values

Parameter	Men	Women
Hemoglobin	14-18 g/dl	12-16 g/dl
RBC	4.7–6.1 million cells per micro liter (µL)	4.2–5.4 million cells per µL
Hematocrit	42%-52%	37%-47%
MCV/mean Corpuscular volume	80-100fL
Platelets	150,000 to 400,000 platelets per micro liter
MCHC	34 ± 2 g/dl.

The most abundantly found elements in blood, erythrocytes (RBC) are red, biconcave disks packed with an oxygen-carrying compound called hemoglobin. Decrease in RBC count leads to anemia. It has been the most efficient measurement in differential diagnosis of microcytic anemia

Hemoglobin — an iron-rich protein that gives blood its red color. Hemoglobin enables red blood cells to carry oxygen from your lungs to all parts of your body and to carry carbon dioxide from other parts of the body to your lungs to be exhaled. It contains four globins proteins bound to a pigment molecule called heme, which contains an ion of iron. Decrease in hemoglobin concentration leads to anemia

MCV has been used to guide the diagnosis of anemia in patients which measures the average size and volume of RBC.

Abnormal size or number of platelets may lead to anemia. Often iron deficiency anaemia is associated with elevated platelet count. Thrombocytopenia also give hint to anemia

Hematocrit or packed cell volume (PCV) gives the clue to anemia because plasma and blood cells are separated by centrifugation. PCV rises when the number of RBCs increases or when the total blood volume is reduced. The PCV falls down when the body decreases the production or increases the destruction of RBC.

Low mean MCHC shows that RBC do not have enough hemoglobin.

Nightingale answered 2 years ago

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