Question

A patient requires an IV of Aminophylline to treat their acute asthma attack.
The physician’s orders are to administer 60.0 mg of Aminophylline per hour via an IV drip. The
required drug comes in 50.0 mL syringes with an Aminophylline concentration of 0.025 M.
The molecular weight of Aminophylline is 420.427 g/Mole.
a. What is the concentration (in mg/mL) of Aminophylline in the syringe?

What rate (mL/hr) should you deliver the medication?

Answer 1

a)  

0.025 M means 0.025 moles in 1000mLsolution

ie, 0.025/1000 (0.000025 )moles in 1 mL solution

0.000025 × 50 moles in 50 mL solution

0.00125 moles in 50 mL syringe

Molecular weight aminophllin =420.427 g/mol

Mass of 0.00125 mole = 0.00125× 420.427 =0.5255 g

= 525.5 mg

So concentration = 525.5/50 =10.51 mg / mL

b) the rate to deliver medication = 60 mg / hour

Here, 10.51 mg in 1mL

1 mg in 1/10.51(0.0952) mL

60 mg in 0.0952 × 60 mL

60 mg in 5.71 mL

So, the rate to deliver medication = 5.71 mL / hour