Explain the target or action of these anticoagulant therapies and identify what if any would be the laboratory tests which should be used to monitor the following anticoagulation therapies?

Explain the target or action of these anticoagulant therapies and identify what if any would be the laboratory tests which should be used to monitor the following anticoagulation therapies? Aspirin ,Coumadin or Warfarin, Heparin (LMW) ,Heparin (UFH) ,Dabigatran(Pradaxa) ,Rivarozaban (Xarelto) ,Argatroban.

Expert Solution

Anti caogulant is the drug used to reduce the blood clot in the body. When we administered this kind of drug in the body, it supress the cloting factors in the body. Now there is need to to understand the cloting factors. Cloting factors helps in caogulation process that is changing liquid form blood to gel form and leads to blood clot.

The laboratory tests that can be used to monitor the anticaogulation therapies are

Test name

Identify

Normal ranges

PT blood test (Prothombin test)/INR (international normalized ratio)

To detect any kind of bleeding disease or cloting abnormality or blood clot.
It check number of second to take blood clot.
It also detect how well the extrinsic cloting factors (VII) and common pathway cloting ( I,II,V, and X)
INR is calculated base on the result of PT
it determine the effectiveness of anticaogulant therapy
It is used to assess wafarin/caumarin effectiveness
The value will be increase more than the normal range for pateint taking anticaogulant drug

10-12 seconds/

INR- 1-2

PPT ( Partial prothrombin time)

It help to assess the intrinsic cloting factor (VIII,IX,XI,XII) and common pathway cloting factor (I,II,V,VIII)
It determine the effectiveness of anticaogulant therapy
it is used to assess heparin therapy effectiveness
The result will be incresase for patient who are taking anticaogulate medication.

30-45 seconds

Nightingale answered 2 years ago

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