Question

In: Biology

Immunology subject For the following three scenarios: 1) please rank their immunogenicity against the allo- or...

Immunology subject

For the following three scenarios:

1) please rank their immunogenicity against the allo- or iso-grafts, i.e., the likelihood of the host to mount immune rejection against the graft.

2) What is the one major factor contributing to the good or poor immunogenicity in these scenarios and provide your explanation for each scenario?

3) What would you do to mitigate immunologically to improve the survival of these hosts?

A) A cancer patient with kidney malignancy

B) A host receiving a kidney transplant from an unrelated donor

C) A Tasmanian devil bit by a devil carrying facial tumor cells

Expert Solution

Please find the answers below:

Answer 1: The ranks can be found as below:

A) A cancer patient with kidney malignancy: Isograft, low immunogenicity

B) A host receiving a kidney transplant from an unrelated donor: Allograft, high immunogenicity

C) A Tasmanian devil bit by a devil carrying facial tumor cells: Allograft, high immunogenicity

Answer 2: The contributing factors can be found as below:

A) A cancer patient with kidney malignancy : The host cells and the diseased cells are from same source sharing MHC compatibility, hence minimized immunogenicity

B) A host receiving a kidney transplant from an unrelated donor: The host cells and the diseased cells are from entirely different sources sharing no MHC compatibility, hence maximized immunogenicity

C) A Tasmanian devil bit by a devil carrying facial tumor cells: The host cells and the diseased cells are from different sources of different species thus sharing absolutely no MHC compatibility, hence maximized immunogenicity

Answer 3: In order to mitigate these immunological problems and enhance survival of these hosts, routine use of immuno-suppressant drugs is highly recommended. This remains the only method to enhance the chances of acceptance of allografts in all recipients.

gladiator answered 2 years ago

1 Please answer the following: a) Rank the following storage systems from slowest to fastest: a....

1 Please answer the following: a) Rank the following storage systems from slowest to fastest: a. Hard-disk drives b. Registers c. Optical disk d. Main memory e. Nonvolatile memory f. Magnetic tapes g. Cache b) How are iOS and Android similar? How are they different?

Please rank the following chemicals by their likelihood (highest = 1, lowest = 3) of staying...

Please rank the following chemicals by their likelihood (highest = 1, lowest = 3) of staying dissolved in water vs. partitioning to a more lipohilic component in water like sediments or dissolved organic carbon. Please provide a justification for your answer. Ethinyl Estradiol: Log Kow = 3.67 DDT: Log Kow = 6.91 Zinc Chloride: Log Kow = 0.15

Which of the following scenarios are typically subject to market failure? (select all that apply) a....

Which of the following scenarios are typically subject to market failure? (select all that apply) a. A private good b. A service, such as national defense, where people can free ride c. An externality d. A price ceiling that is above the equilibrium price e. A good that is non-excludable and non-rival

1) Rank the following from the strongest acid to the weakest acid. Explain with reasons please....

1) Rank the following from the strongest acid to the weakest acid. Explain with reasons please. A) CH3CH2OH B) CH3OCH3 C) CH3—NH—CH3 D) CH3—C≡CH E) CH3—CH=CH2 2) Draw all possible isomers that have the molecular formula C5H12O and name them using the systematic IUPAC name. 3) The following compound has 2 isomers. One isomer has a dipole moment of 0 D, whereas the other has a dipole moment of 2.95 D. Propose structures for the 2 isomers that are consistent...

For each of the following scenarios, perform the three steps in the materiality process: (1) determine...

For each of the following scenarios, perform the three steps in the materiality process: (1) determine overall materiality, (2) determine tolerable misstatement, and (3) evaluate the audit findings. Assume further that the auditor’s firm provides guidance that tolerable misstatement will be set 50% of overall materiality. Scenario 1: Murphy & Johnson is a privately owned manufacturer of small motors for lawnmowers, tractors, and snowmobiles. The components of its financial statements are (1) income before taxes = $21 million, (2) total...

Part 1: Please read the following scenarios. For each scenario, answer the following questions: a) what...

Part 1: Please read the following scenarios. For each scenario, answer the following questions: a) what is the independent variable, b) what is the dependent variable, and c) is this a between-subjects or within-subjects design? A child psychologist wants to determine the effects of cloth versus paper diapers on toilet training. Day-old infants will be used to begin the project. The age at which diapers are no longer needed (to the nearest week) will be determined. A researcher wants to...

1. Please Analyze the following case study on the subject of Procurement that involved significant and...

1. Please Analyze the following case study on the subject of Procurement that involved significant and costly mistakes? Mini case study – Scottish Parliament: the £431m question Scotland’s new parliament building cost more than 10 times the original estimate and opened three years behind schedule. Official cost estimates changed 10 times and ballooned from the initial £40 million estimate to a final £431 million. The procurement model chosen for Holyrood in early 1998 has emerged as the root of the...

1) Consider the following two assets that have rates of return in three equally likely scenarios:...

1) Consider the following two assets that have rates of return in three equally likely scenarios: Scenario M (market) A Strong Growth 15 9 Weak Growth 5 -5 Recession -5 5 a) What is the expected return of each asset? b) What is the risk of each asset when viewed in isolation (standard deviation)? c) Assuming that investors currently hold asset M, what is the risk of asset A in the portfolio sense (beta)?

1. Match the following immunology term with the correct definition: Proteins on B-lymphocytes and APCs that...

1. Match the following immunology term with the correct definition: Proteins on B-lymphocytes and APCs that recognize foreign molecules. Chemical signal that causes increased fluid buildup at infection site. Monocyte that has left circulation Surface glycoprotein located on helper T cells Secreted immunoglobulin Produced from TH2 and functions to activates B-cell Squeezing between cells to leave capillary Organelle within eukaryotic cell that contains digestive enzymes Secreted by phagocytes and targets hypothalamus. Protein that binds and targets cells for phagocytosis Receptor...

PLEASE ANSWER IN EXCEL WITH WORK. An investor has projected three possible scenarios for a project...

PLEASE ANSWER IN EXCEL WITH WORK. An investor has projected three possible scenarios for a project as follows: Pessimistic- NOI will be $200,000 the first year, and then decrease 2 percent per year over a five year holding period. The property will sell for 1.8 million after five year. Most Likely- NOI will be level at $200,000 per year for the next five years(level NOI) and the property will sell for 2 million. Optimistic- NOI will be 200,000 the first...