Question

1. Which of the following is not a lifestyle factor that worsens GERD?
A. Coffee consumption
B. Cigarette smoking
C. Alcohol consumption
D. Chewing gum

2. Chronic cough and excessive phlegm or saliva are hallmark symptoms of?
A. Peptic ulcer disease
B. Laryngopharyngeal reflux
C. NSAID-induced ulcer
D. Gastroesophageal reflux disease

3. Which treatment for GERD is a proton pump inhibitor?
A. Tagamet
B. Axid
C. Pepcid
D. Medium

4. Ulcer formation is a possible adverse reaction of all of the following drugs except
A. aspirin
B. lansoprazole
C. NSAIDs
D. prednisone

5. What is the mechanism of action of domperidone?
A. Neutralizes stomach acid and decreases pPepsi secretion
B. Increases peristalsis by stimulating ACh release
C. Stimulates the production of protective mucus
and stomach bicarbonate
D. Increases peristalsis by blocking peripheral dopamine receptors

6.Which of the following gastrointestinal conditions is not characterized by inflammation?
A. irritable bowel disease
B. ulcerative colitis
C. irritable bowel syndrome
D. Crohn's disease

7. Select the false statement.
A. Ulcerative colitis and Crohn's disease are inflammatory bowel diseases.
B. Irritable bowel syndrome may be associated with
abnormally low levels of the neurotransmitter norepinephrine.
C. In ulcerative colitis and Crohn's disease, the body's immune system recognizes the bacteria that normally inhabit the GI tract as harmful invaders and releases anti-tumor necrosis factor (TNF).
D. Ulcerative colitis produces inflammation in the upper layers of the lining of the small intestine and colon.
E. Lifestyle modification can reduce symptoms of IBS, ulcerative colitis, and Crohn's disease.

8. Which drug(s) may be prescribed only by physicians enrolled in a drug-specific prescribing program?
A. sulfasalazine
B. alosetron
C. tegaserod
D. fiber supplements
E. loperamide

9. Which of the following lifestyle modifications would help reduce symptoms for a patient with Crohn's disease?
A. Limit carbonated beverages
B. Eat small meals
C. Reduce daily water intake
D. A and B
E. All of the above

10. Ulcerative colitis can affect which of the following
locations?

A. Colon
B. Small intestine
C. Mouth
D. All of the above

11. Which statement about glucocorticosteroid use for the treatment of Crohn's disease is false?

A. Glucocorticosteroids decrease inflammation.
B. Glucocorticosteroids increase inflammation.
C. Glucocorticosteroids are immunosuppressants.
D. Glucocorticosteroids reduce flare-ups.

12. Which drug does not induce remission of Crohn's
disease?

A. azathioprine
B. infliximab
C. 6-mercaptopurine
D. methotrexate
E. olsalazine

Answer 1

1. GERD may get worsen with all the given option except the option D, that is chewing gum does not worsen GERD.

2. The correct answer for this question is option B. Laryngo-pharyngeal reflux is most commonly associated with excessive throat clearing (which may be due to formation of excess saliva or phlegm), coughing, hoaresness and globus pharyngeus (lump in the throat sensation). Rest of the options are not associated with LPR.

3. Tagamet is the brand name of Cimetidine which is a famous H-2 receptor blocker therefore it can't be the answer. Axid is also an H-2 receptor blocker brand of Niztidine and so is Pepcid (Famotidine), which of course are not the correct answer. Therefore the only option remains is Medium, but no such brand is known to my knowledge. May be the Esmoperazole brand "Nexium" is mistakenly written as Medium. If this is the case then option D is correct answer.

4. The correct answer of this question undoubtedly is option B, because Lansoprazole is a proton pump inhibitor and is well known antacid, while as the rest of the options are famous for their ulcer causing adverse reactions.

5. Domperidone acts as peripherally selective antagonist of dopamine D2 and D3 receptors and provides relief from nausea by blocking receptors at the chemoreceptor trigger zone (CTZ) at the floor of the fourth ventricle. Therefore option D is the correct answer of the question.

6. Option C Irritable Bowel syndrome is the correct answer of this question. Rest of the option falls under Inflammatory bowel disease category.

7. The correct answer of this question is option D because ulcerative colitis is associated with colon only and not the small intestine. Therefore this statement is false.

8. Option E Loperamide is the correct answer for this question because this drug falls under category of Morphine derived products, and it may become a habit forming drug. Therfore it is included in drug-specific prescribing program.

9. Option D is the correct answer for this question.

10. Ulcerative colitis targets large intestine mainly colon therefore option A is the correct answer.

11. The correct answer of this question is option B. Glucocorticoids increases inflammation is a false statement, rather it decrease inflammation.

12. Option E that is Olsalazine is the correct answer of the question. Rest of the drugs are well used in crohn's disease.