Question

In: Biology

A 37-year-old female presented to the ED with an elevated heart rate, abdominal pain that radiated...

A 37-year-old female presented to the ED with an elevated heart rate, abdominal pain that radiated to her back, weakness and loss of appetite. She had not traveled to West Africa in recent months and she is not pregnant. She had not been well for several days. Her physician order all of the Lactate dehydrogenase isoenzymes. Out of the 5 test, which one is most diagnostic and why? What additional test would you run to confirm your diagnosis?

Expert Solution

INTRODUCTION

Lactate dehydrogenase (LDH) is an enzyme required during the process of converting sugar into energy in cells of the body.

LDH is present in many body tissues, including the liver, heart, pancreas, kidneys, skeletal muscles, lymph tissue, and blood cells.

When tissues are damaged or diseased, they release LDH isoenzymes into the bloodstream.

TYPES OF LDH ISOENZYMES

The isoenzymes of LDH are LDH-1, LDH-2, LDH-3, LDH-4, and LDH5

Different LDH isoenzymes are found in different body tissues. The areas of highest concentration for each type of isoenzyme are:

-LDH-1: heart and red blood cells

-LDH-2: heart and red blood cells

-LDH-3: lymph tissue, lungs, platelets, pancreas

-LDH-4: liver and skeletal muscle

-LDH-5: liver and skeletal muscle

So according to the patient symptom the patient suffering from pancreatitis in which the abdominal pain radiates to back,loss of appetite.

LDH 3 will be elevated because the injury is in pancreas.

Other investigation recommend are

Serum amylase,serum lipase

Liver function test.

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