Question

6. Describe the following prototypes for abortive therapy for migraine headaches. Amerge Maxalt Zomig

7. A 22-year-old woman who works rotating shifts has been prescribed Modafinil (Provigil). Which instructions should the nurse include in drug teaching? (Select all that apply). a. Do not take with food because absorption of the drug will be decreased. b. Make the client aware of orthostatic blood pressure precautions. c. Take as soon as you awaken because the drug can cause insomnia. d. Use a second form of birth control if using oral contraceptives

Answer 1

6) prototype of abortive therapy for migraine headaches for the drugs amerge,maxalt and zomig is same, i.e, sumatriptan

• AMERGE

NARATRIPTAN amerge classifications: Autonomous nervous system agent; adrenergic antagonist ( sympathetic); 5-ht 1 serotonin agonist.

Action: binds to serotonin receptors on intracranial blood vessels resulting in selective vasoconstriction of dilated vessels in the carotid circulation.

Therapeutic effects:- inhibits vasoconstriction of dilated vessels selectively and also the release of proinflammatory neuropeptides. This results in the relief of acute migraine headache attacks

Prototype:- sumatriptan

• MAXALT (RIZATRIPTAN BENZOATE)

Action:- selective (5HT 1B/1D) receptor agonist. The agonist effects of 5 HT 1B/1D reverse the vasodilation of cranial blood vessels associated with migraine

Therapeutic effects:- activation of the 5-HT 1B/1D receptors reduces the pain pathways associated with the migraine headache as well as reversing vasodilation of cranial blood vessels.

• Zomig

Zolmitriptan ( nasal spray classifications)

Action:- selective serotonin receptor agonist. The agonist effects at 5- HT 1 B/ 1D reverse the vasodilation of cranial blood vessels associated with migraine.

Therapeutic effects:- Activation of these receptors also reduces the pain pathways associated with migraine headache in addition to causing vasoconstriction.

7)drug teaching for modafinil

Modafinil is a drug used for excessive sleepiness caused by narcolepsy or shift work sleep disorder.

- Take as soon as you awaken because the drug can cause insomnia

- use a second formof birth control if using contraceptives. ( Because contacepives that are using along with this drug is not effective.)