In: Biology
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https://askdrsilverman.com/wp-content/uploads/2016/04/epigenetics-and-environment-nature-2012.pdf
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Introduction:
Epigenetic phenomena in animals and plants are mediated by DNA methylation and stable chromatin modifications. There has been considerable interest in whether environmental factors modulate the establishment and maintenance of epigenetic modifications, and could thereby influence gene expression and phenotype.
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Peripheral blood leukocytes in children from rural Gambia that were conceived during either the dry season or the rainy season. The rainy season is nutritionally challenging and children conceived during this season showed slightly increased CpG methylation at some of the loci. The genes that were found to be affected in the Dutch hunger winter cohorts were not altered in the Gambia study, indicating that different nutritional challenges have different epigenetic outcomes.
Methods used
Research will be boosted by the expanding use of next-generation DNA sequencing technologies.Applications include chromatin immunoprecipitation followed by DNA sequencing to assess the genomic distribution of histone modifications, histone variants and nuclear proteins and globalDNA methylation analysis through the sequencing of bisulphite-converted genomic DNA. Combined with appropriate statistical and bioinformatic tools.