Question

With respect to central tolerance during T cell development what is clonal diversion (A) versus clonal deletion(B)?

A)____________________ B)__________________

Answer 1

T cell central tolerance is the ability to become self tolerant and to recognize foreign antigens in combination with MHC molecules (MHC restriction) is acquired only after going through the process of thymic selection.t cell tolerance operates through 2 different mechanisms :-

A) clonal diversion : the T cell with high affinity or intermediate affinity towards self antigen present on dendritic MHC I class are potentially dangerous cells so the process of re-programming of these cells to differentiate into regulatory T (Treg) cells is known as clonal diversion.

B)Clonal deletion: it is negative thymic selection in which T cells bind with mTECs (medullary thymic epithelial cells ), dendritic cells and macrophages bearing class 1 MHC and class II MHC and self antigen and has high affinity for self antigen that are potentially dangerous cells are eliminated by apoptosis. This overall process of elimination of Tcell which have high or intermediate affinity for self antigen present on MHC I and II class through apoptosis known as clonal deletion.