Name and lists the zones of the metaphysis from epiphysis to diaphysis

Expert Solution

Metaphysis contains the growth plate in the long bone and is the narrow shaft between epiphysis and diaphysis. It has a zonal morphology and can be classified into 5 zones from epiphysis to diaphysis as follows:

Zone of reserve: This is the place where unmodified hyaline cartilage is present. Quiscent chondrocytes are found at this end.
Zone of proliferation: This is the zone of cell division. Chondrocytes undergo rapid mitosis to form cellular columns separated by deeply staining matrix.
Zone of maturation and hypertrophy: This is the maturation zone in which chondrocytes mature, mitosis is stopped and cells begin to hypertrophy by accumulating alkaline phosphatase, glycogen and lipids.
Zone of calcification: This is the zone of apoptosis. Hypertrophied chondrocytes undergo apoptosis and calcification of cartillagenous matrix begins.
Zone of ossification: The calcified cartilage is broken down by the osteoclasts and osteoblasts from the diaphysial side and replaced with mineralized bone tissue.

Sydney Mullin answered 2 years ago

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