A HIV positive patient of European ancestry has been referred to you for treatment. A standard treatment...

A HIV positive patient of European ancestry has been referred to you for treatment. A standard treatment is a cocktail of retroviral drugs including abacavir. Before prescribing this, you review the patient’s records and see that one of her cousins had a lethal reaction to abacavir treatment.

a. What test or tests would you do on the patient before starting her on abacavir?

b. What results of your test would cause you to not make this prescription

c. Explain to the patient, who is not a scientist, what tests you want to do and why you want to do these tests.

PLEASE BE SPECIFIC

Expert Solution

Retroviral drug abacavir is a reverse transcriptase inhibitor used for the treatment of HIV infected patients but it may have lethal effect due to hypersensitivity reaction. it mediated by major histocompatibility complex class i (HLA B 5701)

a. to test the hypersensitivity skin patch test will be performed to test the associate hypersensitivity in the patient.

b. if the skin patch test give hypersensitive reaction then, the patient can not be prescribed with the abacavir. if, there is no sign of any kind of reactivity of hypersensitivity, then abacavir can be used for the retroviral treatment without any hesitation of lethality in the patient.

c. tell patient that when he was going through the reports associated to you, contains an statement that your cosine have some problem with abacavir drug, so before prescribing you the same drug, i wanted to be sure that you do not have any problem from that drug because genetics of your family may affect you also but not surly..

gladiator answered 2 years ago

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