Question

Match the side effects to the receptor

Using the supplied table, complete the information that is missing.

Explain what clinical side effects would be presented using anti-depressant medication that blocks/antagonises

that particular receptor or transporter.

NOTE: Only focus on blocking (Antagonising) the receptor/transporter

Blocking Receptor/Transporter	Possible clinical Side Effects/Benefits
SERT Monoamine transporter Serotonin reuptake transporter Transporter Increase the Serotonin around synaptic axonal end
NET Monoamine Transporter Noradrenaline reuptake transporter Bring stuff back to the neuron
5HT2A GPCR Post synaptic receptor Excitatory receptor
5HT2C Also excitatory receptor GPCR
5HT3 Like -sertrons E.g. Ondansertron
A1AR - alpha 1 adrenergic receptor Cardio-like prazosin Blocking NT level? Alpha 1 Noradrenaline receptor Antagonizing NA: lower the NA
A2AR - Alpha 2 adrenergic receptor Autoreceptors Feedback sensor Negative GPCR feedback loop Sensor: turning things off Agonist binds to the autoreceptor, telling don’t make more Turn off Antagonists: essentially its not increasing/decreasing production Stop the “Turning off the feedback”
H1 - Histamine
M1 NT for muscarinic receptor Acetylcholine	Dry mouth, dry eyes, tachycardia, sweating, constipation, urinary retention, blurred vision, dizziness, drowsiness (Symptoms such as anti-cholinergic effects)

Answer 1

1.SERT the side effects are orthostatic hypotension and sedation by blocking the serotonin reuptake receptors.

2.NET

Side effects are: headache, trouble sleeping, decreased appetite,unpleasant taste in your mouth,nervousness

sexual dysfunction

vomiting

diarrhea or constipation,

dry mouth,weight lossm,mood swings

3.5HT2A: hallucinations, potent anti inflammatory effects

4.5HT2C

Drug paroxetine cause anti cholinergic symptoms like dry mouth, urinary retention, constipation

5.5HT3: headache, constipation,

6.alpha 1adrenergic: dizziness, drowsiness, nausea, headache

7. Alpha 2 adrenergic: dizziness, orthostatic hypotension, reflex tachycardia