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Design a formulation for each of the following emulsions. Name the ingredients, specify the role fo...

Design a formulation for each of the following emulsions.

Name the ingredients, specify the role fo each one, calculate required HLB and ratio of emulsifying agents in each formulation.

A- local emulsion of collagen with hydration effect

B- parenteral emulsion of propofol

Solutions

Expert Solution

Emulsion used to make medicine more palatable to improve effectiveness by controlling dosage of active ingredients and to provide improved aesthetics for drugs such as ointments.

A. Different topical oil in water emulsions based on natural ingredients such as collagen hydrolysate vegetables oil mixtures. Ingredients are in oil phase : mixture of coconut,almond,avocado oil

In water phase : levender oil. Plant based products containing glycerol stearate and potassium stearate was Incorporated concentration rage is 4 to 5% and modifier xanthan gum was used in 0.2 to 1% .

B.Parenteral emulsion of propofol:propofol is a highly lipophilic anesthetic (2,6-disopripylphenol) Preparation is made with ingredients:

1% propofol . 10%Soyabean oil. 1.2 %purified egg phospholipid as an emulsifier with 2.25%glycerol as a tonicity adjusting agent and sodium hydroxide to adjust the PH.

Uses: Soyabean oil hold the bulk of the propofol in medium that can be stabilized and dispersed.Lecithin servers as an emulsifier to stabilize the Small propofol .Soyabean oil droplets in aqueous dispersion and glycerol maintains the formulation of isotonic with blood.PH of the emulsion is adjusted with the base sodium hydroxide to around7 to 8.5 for optimal emulsion stability.

Propofol emulsion : Benzyle alcohol1.5 mg/ml and sodium benzoate0.7 mg/ml to inhibit the rate of growth of microorganisms up to 12 hours in the events of accidental extrinsic contamination.

New preparation add EDTA .it works as anti micro bacterial activity.

Nightingale answered 2 years ago
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