Question

Ovarian cancer patients whose tumors had large numbers of infiltrating lymphocytes had a high rate of recurrence after the tumor removed relative to those tumors that lacked infiltrated lymphocytes.

True or false

Answer 1

ANSWER :- TRUE.

Yes ovarian cancer patients whose tumor had large numbers of infiltrating lymphocytes had a high rate of recurrence after the tumor removed relative to those tumors that lacked infiltrating lymphocytes.

T-cells transfer therapy :- In cancer patients, a therapy known as T-cell transfer therapy is given to patients (like ovarian cancer patients), for the treatment of cancer. In such type of cancer patients, the tumor generates a mechanism by which it prevents the immune system by providing a highly suppressive environment.

Immune-activated tumor infiltrating lymphocytes (TILs) in the ovarian tumors tissue testify the immune system is the trigger in this neoplasms. This TILs are related with better prognosis, more chemosensitivity.

Basically, these type of immune cells moved from blood into tumors and then these TILs recognise and Kills the cancer cells.

In the T-cells transfer therapy, these TILs are removed from ovarian patients tumor and then grown in large numbers in the laboratory, and then it transferred to the patient to help the immune system to kill the cells. So, these cells then have the property of recurrence as the selected lymphocytes are treated with the substance that make them to grow in large numbers quickly. This therapy is very effective in treatment of ovarian cancer. The reason is that the lymphocytes that are present in or near the tumor already have the ability to recognise tumor cells. But, before this therapy, they are not enough to kill the tumor cells. So, readymade lymphocytes are being given to the patient in a very large quantity so that they be able to kill then tumor.

This T-cell transfer therapy is also known as the adaptive therapy or adoptive immunotherapy or immune cell therapy.