Question

 

1). Zinc sulfate 0.06, Boric acid qs, purified water ad 30mL, Make isoton. sol., sig drop in eyes.

How much boric acid should be used in compounding the precription?

2). Oxymetazoline hydrochloride 1/2 %, Boric acid solution qs, Purified water ad 15mL, .Make isoton. sol. Sig. for the nose, as decongestant.

How many milliliters of a 5% solution of boric acid should be used in compounding the prescription?

3). Naphazoline hydrochloride 1%, Sodium Chloride qs, Purified water ad 30mL, Make isoton. sol., Sig use as directed in the eye.

How many milligrams of sodium chloride should be used in compounding the prescription? Use the freezing point depression method or the sodium chloride equivalent method.

Answer 1

3). Naphazoline hydrochloride 1%, Sodium Chloride qs, Purified water ad 30mL, Make isoton. sol., Sig use as directed in the eye.

How many milligrams of sodium chloride should be used in compounding the prescription? Use the freezing point depression method or the sodium chloride equivalent method.

NaCl “E”QUIVALENT = Mole of NaCl gL^-1 * i_{Drug / Mole of drug gL}^{-1 *} _iNaCl

E” forNaphazoline HCl = 58.5gL^-1 *1.8/ 247gL^-1    *1.8

= 0.2368 g NaCl

1 g of Naphazoline HCl has the osmotic Pressur as 0.2368 g of NaCl

0.01g* 30 mL/100 mL= 0.003 g Naphaz.

0.2368 g NaCl*0.003 g Naph= 0.0007104g NaCl

1 g Naphz

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1). Zinc sulfate 0.06, Boric acid qs, purified water ad 30mL, Make isoton. sol., sig drop in eyes.

How much boric acid should be used in compounding the precription?

answer = 0.501 g

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Oxymetazoline Hydrochloride ½%
Boric Acid Solution q.s.
Purified Water ad 15
Make isoton. sol.
Sig. For the nose, as decongestant.

How many milliliters of a 5% solution of boric acid should be used in compounding the prescription?

answer= 4.62 mL

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