Increased gene expression from the Ink4A locus leads to inhibition of cyclin E-CDK2. True or False

Increased gene expression from the Ink4A locus leads to inhibition of cyclin E-CDK2.

True or False

Expert Solution

Cyclin Eis a protein that binds to the Cdk2 receptor in the G1 phase which leads to the transition from G1 to S phase of the cell cycle i.e this complex Cyclin E Cdk 2 initiates the the cell division. The Cyclin E Cdk2 phosphorylates the retinoblastoma protein which leads to the progression of the G1 phase into S phase.The overexpression of this cyclin dependent kinase family protein is also associated with the tumorgenesis (cancer) due to the increased cell proliferation which is the characteristic feature of tumor.

Whereas to supress this activity of the protein the INK4A locus which encodes for proteins such as p15INK4A inhibits the cyclin dependent kinase inhibitors and thus regulate the p53 pathway. This protein directly binds to the CDK and hence induce the G1 cell cycle arrest by preventing the phosphorylation of retinoblastoma protein.

Therefore, the increased expression of this protein will inhibit the Cyclin E CDK 2.

gladiator answered 2 years ago

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