In: Nursing
Which of the following best explains this phenomenon in the case of phenytoin? a. The high oral bioavailability of phenytoin, b. The high degree of plasma protein binding of phenytoin, c. The low Km (Michaelis-Menten constant) for phenytoin metabolism, or d. The low renal clearance rate for phenytoin?
Ans-
As we know that phenytoin is an medication or a drug used to cure or treat the seizure..it is also calles as anti seizure drug Which is use in case of partial seizures, tonic clonic seizure, and absence seizure.
Phenytoin also use in sometime treating of arrhythmia and neuropathic pain
As belive that phenytoin cause the voltage dependent block of sodium channels which cause the steady state convention of sodium ion in body Which help in stablising of the cns and reduce the chances of atteck of seizure
So we can say that the best phenonphen for explaining of phenytoin are.
(B)- the high digree di plasma proteins binding of phenytoin and
(C) the law Km that is Michaelis memtain constant for phenytoin metabolism..
Because it will.act on cns and it must have to lipophilic so that it can penetrate in blood brain barrier and act on stablising or blocking of Sodium.channel and prevent seizure..
Hope u understand the answer..