In: Biology
Bar is a dominant mutation on the Drosophila X-chromosome. A Bar male crossed to a wildtype female giving the following results:
Bar females 998
wild type males 1021
wild type female 1
Remember: in Drosophila two X-chromosomes make a female fly and one X-chromosome makes a male; the Y is irrelevant. XXX is lethal.
Part I: What are the complete and exact genotypes of each parent and each type of offspring?
female parent:
male parent:
Bar female F1:
wild type male F1:
wild type female F1:
Part II: (a) What went wrong during meiosis, (b) in what fly, and (c) at exactly what stage of meiosis?
a)
b)
c)
Answer :
Part I- Genotype of male parent is XB Y
Female parent- X+ X+
Bar female F1- X+XB
Wild type male F1- X+ Y
Wild type female F1- X+X+Y ( Exceptional)
Part II- (a)The exceptional F1 flies are the result of abnormal X chromosome behavior during the process of meiosis in the female parent. Usually, the X chromosomes in these females disjoin or segregate from each other during meiosis. However, sometimes they might fail to do so producing an egg with two X chromosomes or an egg with no X chromosome.
Fertilization of these abnormal eggs with normal sperm leads to an unusual number of chromosomes in their offsprings resulting in unexpected phenotypes.
(b) The female parent
(c) Anaphase I stage of Meiosis where segregation of chromosomes takes place.