Question
In: Nursing
Mr. G has been admitted to your unit with a diagnosis of antiglomerular basement membrane disease...
Mr. G has been admitted to your unit with a diagnosis of antiglomerular basement membrane disease (Goodpasture syndrome) following a strep throat infection.
Explain how Mr. G’s strep throat infection is related to the development of Goodpasture Syndrome?
What area of the body is affected other than the kidneys?
Solutions
Expert Solution
Question 1
Goodpasture syndrome is an inflammatory disease which is majorly caused by Streptococcal infection.
Throat infection (due to Streptococcal microorganism)
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Streptococcal microorganism enters in to blood causing reach out to Kidney
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Kidney’s basement membrane which made up specific type of collagen called type 4(consist of multiple Alpha chains)
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Triggers the immune system by antigen and antibody reaction Damage to the kidney causes symptoms like hematuria (blood in urine and Proteinuria)
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Damage to the kidney causes symptoms like hematuria (blood in urine and Proteinuria)
Question 2
Answer- Lungs
Likewise these basement membranes present in lung alveoli and due to antigen antibody reaction lungs are getting damaged and causing cough (due to poor gas exchange and hemoptysis bloody sputum).
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