In: Statistics and Probability
The researcher from Scenario I decides to compare a second dose-effect curve with carboxycotton to determine if the novel opioid has the capacity to induce tolerance (i.e., a rightward shift in the dose-effect function; a larger dose is required to produce the same effect). The researcher takes the carboxycotton-treated mice from the first experiment (subjects 6-10 from above) and administers cumulative doses of carboxycotton. He then measures tail withdrawal latency as before. On the following day, he administers cumulative doses of carboxycotton again to determine if tolerance development occurred. The results of this experiment are presented in the table below.
Carboxycotton ED50 values |
||
Subject |
ED50 (mg/kg) from first dose-effect curve |
ED50 (mg/kg) from second dose-effect curve |
6 |
0.10 |
0.25 |
7 |
0.35 |
0.15 |
8 |
0.80 |
0.75 |
9 |
0.95 |
1.00 |
10 |
0.50 |
0.63 |
t( ____) = _____, p = _______
______________________
Yes or No (circle one)