The researcher from Scenario I decides to compare a second dose-effect curve with carboxycotton to determine...

The researcher from Scenario I decides to compare a second dose-effect curve with carboxycotton to determine if the novel opioid has the capacity to induce tolerance (i.e., a rightward shift in the dose-effect function; a larger dose is required to produce the same effect). The researcher takes the carboxycotton-treated mice from the first experiment (subjects 6-10 from above) and administers cumulative doses of carboxycotton. He then measures tail withdrawal latency as before. On the following day, he administers cumulative doses of carboxycotton again to determine if tolerance development occurred. The results of this experiment are presented in the table below.

Carboxycotton ED₅₀ values
Subject	ED₅₀ (mg/kg) from first dose-effect curve	ED₅₀ (mg/kg) from second dose-effect curve
6	0.10	0.25
7	0.35	0.15
8	0.80	0.75
9	0.95	1.00
10	0.50	0.63

Write the name of the specific statistical test that is appropriate for these data: ______________________

Perform the test you identified inquestion 7 above using the statistical software (e.g., GraphPad Prism, Excel, R) of your choice. Be sure to perform a two-tailed test. Please round all answers to two decimal places, where appropriate.

Report the mean of differences between dose-effect curves: _______________
Report the standard deviation of differences between dose-effect curves: __________________
Report the standard error of the mean of differences between dose-effect curves: __________________
Report the results of the statistical test in the spaces below:

t( ____) = _____, p = _______

Report the 95% confidence interval (LL,UL) for the difference between dose-effect curves:

______________________

Compare the results from the 95% confidence interval in question 9 with the results from the statistical test in question 8. Is there sufficient evidence to reject the H₀ and claim that that there is a potency difference between the first dose-effect curve and the second dose-effect curve in carboxycotton-treated mice?

Yes or No (circle one)

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orchestra answered 2 years ago

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