Question

In: Statistics and Probability

The researcher from Scenario I decides to compare a second dose-effect curve with carboxycotton to determine...

The researcher from Scenario I decides to compare a second dose-effect curve with carboxycotton to determine if the novel opioid has the capacity to induce tolerance (i.e., a rightward shift in the dose-effect function; a larger dose is required to produce the same effect). The researcher takes the carboxycotton-treated mice from the first experiment (subjects 6-10 from above) and administers cumulative doses of carboxycotton. He then measures tail withdrawal latency as before. On the following day, he administers cumulative doses of carboxycotton again to determine if tolerance development occurred. The results of this experiment are presented in the table below.

Carboxycotton ED50 values

Subject

ED50 (mg/kg) from first dose-effect curve

ED50 (mg/kg) from second dose-effect curve

6

0.10

0.25

7

0.35

0.15

8

0.80

0.75

9

0.95

1.00

10

0.50

0.63

  1. Write the name of the specific statistical test that is appropriate for these data: ______________________

  1. Perform the test you identified inquestion 7 above using the statistical software (e.g., GraphPad Prism, Excel, R) of your choice. Be sure to perform a two-tailed test. Please round all answers to two decimal places, where appropriate.

  1. Report the mean of differences between dose-effect curves: _______________
  2. Report the standard deviation of differences between dose-effect curves: __________________
  3. Report the standard error of the mean of differences between dose-effect curves: __________________
  4. Report the results of the statistical test in the spaces below:

                        t( ____) = _____, p = _______

  1. Report the 95% confidence interval (LL,UL) for the difference between dose-effect curves:

______________________

  1. Compare the results from the 95% confidence interval in question 9 with the results from the statistical test in question 8. Is there sufficient evidence to reject the H0 and claim that that there is a potency difference between the first dose-effect curve and the second dose-effect curve in carboxycotton-treated mice?

Yes or No (circle one)

Solutions

Expert Solution


Related Solutions

In a biomedical study with rats, a dose-response investigation is used to determine the effect of the dose of a toxicant on their survival time.
In a biomedical study with rats, a dose-response investigation is used to determine the effect of the dose of a toxicant on their survival time. The toxicant is one that is frequently discharged into the atmosphere from jet fuel. For a certain dose of the toxicant, the study determines that the survival time, in weeks, has a gamma distribution with α = 5 and β = 10. What is the probability that a rat survives no longer than 60 weeks?
1. A researcher decides to compare three groups of subjects on a decision-making task, to see...
1. A researcher decides to compare three groups of subjects on a decision-making task, to see if people make riskier decisions when their friends were around. She compares three groups, either with their friends present, absent, or a stranger nearby. She conducts a one-way between-subjects ANOVA and obtains the following values for her F-table Source of Error SS df MS F BG 2024 2 1012 3.42 Error 5328 18 296 Total 14712 20 2. A researcher is interested in studying...
Determine the area inside the first curve but outside the second curve. r=2sin2θ r=1
Determine the area inside the first curve but outside the second curve. r=2sin2θ r=1
Research Scenario: A researcher is attempting to determine the effects of sex and sleep deprivation on...
Research Scenario: A researcher is attempting to determine the effects of sex and sleep deprivation on a reaction time task. Participants (5 men; 5 women) in an experiment are given a computerized search task. They search a computer screen of various characters and attempt to find a particular character on each trial. When they find the designated character, they press a button to stop a timer. Their reaction time (in ms) on each trial is recorded (note, so the lower...
#2 In the following table, indicate the effect of each scenario on the aggregate demand curve....
#2 In the following table, indicate the effect of each scenario on the aggregate demand curve. Scenario Change in Aggregate Demand Government spending increases.(Increases or Decrease) The amount of taxes collected decreases. (Increases or Decreases) #4 Why does a reduction in taxes have a smaller multiplier effect than an increase in government spending of an equal amount? A tax cut directly injects zero new spending into the economy because the government has purchased no new goods and services. An increase...
A researcher wants to determine whether or not a given drug has any effect on the...
A researcher wants to determine whether or not a given drug has any effect on the score of a human subject performing a task of ESP sensitivity. He randomly assigns his subjects to one of two groups. 900 subjects in group 1 (treatment group) receive the drug. In contrast, 1000 subjects in group 2 (control group) receive a placebo. For the drug group, the mean score on the ESP test was 15, SD=4. For the no-drug group, the mean =9,...
5) In the OmniPower Bars scenario, your business objective, to determine the effect that price and...
5) In the OmniPower Bars scenario, your business objective, to determine the effect that price and in-store promotional expenses will have on sales, calls for examining a multiple regression model in which the price of an OmniPower Bar in cents (X1) and the monthly budget for in-store promotional expenses in dollars (X2) are the independent variables and the number of OmniPower Bars sold in a month (Y) is the dependent variable. The data has been collected from a sample of...
Consider a scenario in which a researcher wishes to determine which one of four treatment plans...
Consider a scenario in which a researcher wishes to determine which one of four treatment plans to control high blood pressure (HBP) is best; the treatments considered are: medication, diet, exercise, and yoga/meditation. What confounding variables might there be for the experiment? In addition to treatment plan, what else - other than the type of treatment - might the researcher consider? What insights or suggestions would you offer the researcher?
The researcher in exercise number 5 from the Mod. 11 assignment decides to conduct the same...
The researcher in exercise number 5 from the Mod. 11 assignment decides to conduct the same study using a within-subjects design in order to control for differences in cognitive ability. He selects a random sample of participants and has them study different material of equal difficulty in both the music and no music conditions. They are measured on an interval-ratio scale and are normally distributed. The scores are: Music           No Music 6                   10 7                  7 6                  8 5                  7 6                  7...
To determine the effect of various cooling devices during exercise, a researcher assigns 10 people to...
To determine the effect of various cooling devices during exercise, a researcher assigns 10 people to each of the following four groups: No Cooling Device, Only Head Cooling Device, Only Vest Cooling Device, Both Head and Vest Cooling Device. The researcher takes the body temperature of each individual after exercise and runs an ANOVA to test the null hypothesis that . Here is the R input: > NoCool=c(102,104,101,102,103,101,99,102,100,100)> HeadCool=c(102,102,100,101,103,101,99,101,101,100) > VestCool=c(101,102,100,100,102,100,99,101,100,100)> HeadVestCool=c(100,99,99,100,100,99,98,100,99,99) > Device = c(rep("None",10),rep("Head Only",10),rep("Vest Only",10),rep("Head and Vest",10))...
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT