1. Does Unc-22 have a conserved region, like HD domain, zimc fingers if so, where is...

1. Does Unc-22 have a conserved region, like HD domain, zimc fingers if so, where is it located?

Expert Solution

Unc-22 = Twitchin
The ortholog of human Titin gene
It regulates muscle contraction and relaxation.
It also plays a major role in the organization of sarcomeres in the muscles.
It is expressed at the outer edge of the A-band.

>Protein sequence
MVGAPRFTQKPSIQQTPTGDLLMECHLEADPQPTIAWQHSGNLLEPSGRVVQTLTPLGGS
LYKATLVIKEPNAGDGGAYKCTARNQLGESNANINLNFAGAGGDEAKSRGPSFVGKPRII
PKDGGALIVMECKVKSASTPVAKWMKDGVPLSMGGLYHAIFSDLGDQTYLCQLEIRGPSS
SDAGQYRCNIRNDQGETNANLALNFEEPDPSERQERKRSTASPRPSSRGPGSRPSSPKKS
MKSREGTPKRTLKPREGSPSKKLRSRTSTPVNEEVSQSESRRSSRTDKMEVDQVSGASKR
KPDGLPPPGGDEKKLRAGSPSTRKSPSRKSASPTPSRKGSSAGGAASGTTGASASATSAT
SGGSASSDASRDKYTRPPIVLEASRSQTGRIGGSVVLEVQWQCHSSTIIEWYRDGTLVRN
SSEYSQSFNGSIAKLQVNKLTEEKSGLYKCHAKCDYGEGQSSAMVKIEQSDVEEELMKHR
KDAEDEYQKEEQKSQTLQAETKKRVARRSKSKSKSPAPQAKKSTTSESGRQEASEVEHKR
SSSVRPDPDEESQLDEIPSSGLTIPEERRRELLGQVGESDDEVSESISELPSFAGGKPRR
KTDSPPKQDDMFSRDTLLRKTTTSTKNESSTVEEKTKLRKTVKKVDGELDFKAMVKLKKV
KKEEGGTTEKSGFPLDHADSTSSVLSQESRSRRGSNAPFAKDGLPEQPANPFAQLKKVKS
GAGGLEKSDSMASLKKLDLKKGKIDDNSDGAFKVQLKKVVKKEVKESTISVKEKNGTESG
IKTEFKMEKRERTTLQKYEKTDSDGSKKEDKPKKVSIAPVSTNKSSDDEPSTPRHHKEVE
EKSTSEELKAKVAGRQVGQKRNGAQKPEEPKNLLSQIQLKKVTKKAHDDTNELEGIKLKK
VTTVPKHVADDDSQSESESRRGSVFGELRRGSRAPRDSADNSRRDSIRRSSIDMRRESVQ
EILEKTSTPLVPSGASGSAPKIVEVPENVTVVENETAILTCKVSGSPAPTFRWFKGSREV
ISGGRFKHITDGKEHTVALALLKCRSQDEGPYTLTIENVHGTDSADVKLLVTSDNGLDFR
AMLKHRESQAGFQKDGEGGGAGGGGGEKKPMTEAERRQSLFPGKKVEKWDIPLPEKTVQQ
QVDKICEWKCTYSRPNAKIRWYKDRKEIFSGGLKYKIVIEKNVCTLIINNPEVDDTGKYT
CEANGVPTHAQLTVLEPPMKYSFLNPLPNTQEIYRTKQAVLTCKVNTPRAPLVWYRGSKA
IQEGDPRFIIEKDAVGRCTLTIKEVEEDDQAEWTARITQDVFSKVQVYVEEPRHTFVVPM
KSQKVNESDLATLETDVNDKDAEVVWWHDGKRIDIDGVKFKVESSNRKRRLIINGARIED
HGEYKCTTKDDRTMAQLIVDAKNKFIVALKDTEVIEKDDVTLMCQTKDTKTPGIWFRNGK
QISSMPGGKFETQSRNGTHTLKIGKIEMNEADVYEIDQAGLRGSCNVTVLEAEKRPILNW
KPKKIEAKAGEPCVVKVPFQIKGTRRGDPKAQILKNGKPIDEEMRKLVEVIIKDDVAEIV
FKNPQLADTGKWALELGNSAGTALAPFELFVKDKPKPPKGPLETKNVTAEGLDLVWGTPD
PDEGAPVKAYIIEMQEGRSGNWAKVGETKGTDFKVKDLKEHGEYKFRVKALNECGLSDPL
TGESVLAKNPYGVPGKPKNMDAIDVDKDHCTLAWEPPEEDGGAPITGYIIERREKSEKDW
HQVGQTKPDCCELTDKKVVEDKEYLYRVKAVNKAGPGDPCDHGKPIKMKAKKASPEFTGG
GIKDLRLKVGETIKYDVPISGEPLPECLWVVNGKPLKAVGRVKMSSERGKHIMKIENAVR
ADSGKFTITLKNSSGSCDSTATVTVVGRPTPPKGPLDIADVCADGATLSWNPPDDDGGDP
LTGYIVEAQDMDNKGKYIEVGKVDPNTTTLKVNGLRNKGNYKFRVKAVNNEGESEPLSAD
QYTQIKDPWDEPGKPGRPEITDFDADRIDIAWEPPHKDGGAPIEEYIVEVRDPDTKEWKE
VKRVPDTNASISGLKEGKEYQFRVRAVNKAGPGQPSEPSEKQLAKPKFIPAWLKHDNLKS
ITVKAGATVRWEVKIGGEPIPEVKWFKGNQQLENGIQLTIDTRKNEHTILCIPSAMRSDV
GEYRLTVKNSHGADEEKANLTVLDRPSKPNGPLEVSDVFEDNLNLSWKPPDDDGGEPIEY
YEVEKLDTATGRWVPCAKVKDTKAHIDGLKKGQTYQFRVKAVNKEGASDALSTDKDTKAK
NPYDEPGKTGTPDVVDWDADRVSLEWEPPKSDGGAPITQYVIEKKGKHGRDWQECGKVSG
DQTNAEILGLKEGEEYQFRVKAVNKAGPGEASDPSRKVVAKPRNLKPWIDREAMKTITIK
VGNDVEFDVPVRGEPPPKKEWIFNEKPVDDQKIRIESEDYKTRFVLRGATRKHAGLYTLT
ATNASGSDKHSVEVIVLGKPSSPLGPLEVSNVYEDRADLEWKVPEDDGGAPIDHYEIEKM
DLATGRWVPCGRSETTKTTVPNLQPGHEYKFRVRAVNKEGESDPLTTNTAILAKNPYEVP
GKVDKPELVDWDKDHVDLAWNAPDDGGAPIEAFVIEKKDKNGRWEEALVVPGDQKTATVP
NLKEGEEYQFRISARNKAGTGDPSDPSDRVVAKPRNLAPRIHREDLSDTTVKVGATLKFI
VHIDGEPAPDVTWSFNGKGIGESKAQIENEPYISRFALPKALRKQSGKYTITATNINGTD
SVTINIKVKSKPTKPKGPIEVTDVFEDRATLDWKPPEDDGGEPIEFYEIEKMNTKDGIWV
PCGRSGDTHFTVDSLNKGDHYKFRVKAVNSEGPSDPLETETDILAKNPFDRPDRPGRPEP
TDWDSDHVDLKWDPPLSDGGAPIEEYQIEKRTKYGRWEPAITVPGGQTTATVPDLTPNEE
YEFRVVAVNKGGPSDPSDASKAVIAKPRNLKPHIDRDALKNLTIKAGQSISFDVPVSGEP
APTVTWHWPDNREIRNGGRVKLDNPEYQSKLVVKQMERGDSGTFTIKAVNANGEDEATVK
INVIDKPTSPNGPLDVSDVHGDHVTLNWRAPDDDGGIPIENYVIEKYDTASGRWVPAAKV
AGDKTTAVVDGLIPGHEYKFRVAAVNAEGESDPLETFGTTLAKDPFDKPGKTNAPEITDW
DKDHVDLEWKPPANDGGAPIEEYVVEMKDEFSPFWNDVAHVPAGQTNATVGNLKEGSKYE
FRIRAKNKAGLGDPSDSASAVAKARNVPPVIDRNSIQEIKVKAGQDFSLNIPVSGEPTPT
ITWTFEGTPVESDDRMKLNNEDGKTKFHVKRALRSDTGTYIIKAENENGTDTAEVKVTVL
DHPSSPRGPLDVTNIVKDGCDLAWKEPEDDGGAEISHYVIEKQDAATGRWTACGESKDTN
FHVDDLTQGHEYKFRVKAVNRHGDSDPLEAREAIIAKDPFDRADKPGTPEIVDWDKDHAD
LKWTPPADDGGAPIEGYLVEMRTPSGDWVPAVTVGAGELTATVDGLKPGQTYQFRVKALN
KAGESTPSDPSRTMVAKPRHLAPKINRDMFVAQRVKAGQTLNFDVNVEGEPAPKIEWFLN
GSPLSSGGNTHIDNNTDNNTKLTTKSTARADSGKYKIVATNESGKDEHEVDVNILDIPGA
PEGPLRHKDITKESVVLKWDEPLDDGGSPITNYVVEKQEDGGRWVPCGETSDTSLKVNKL
SEGHEYKFRVKAVNRQGTSAPLTSDHAIVAKNPFDEPDAPTDVTPVDWDKDHVDLEWKPP
ANDGGAPIDAYIVEKKDKFGDWVECARVDGKTTKATADNLTPGETYQFRVKAVNKAGPGK
PSDPTGNVVAKPRRMAPKLNLAGLLDLRIKAGTPIKLDIAFEGEPAPVAKWKANDATIDT
GARADVTNTPTSSAIHIFSAVRGDTGVYKIIVENEHGKDTAQCNVTVLDVPGTPEGPLKI
DEIHKEGCTLNWKPPTDNGGTDVLHYIVEKMDTSRGTWQEVGTFPDCTAKVNKLVPGKEY
AFRVKAVNLQGESKPLEAEEPIIAKNQFDVPDPVDKPEVTDWDKDRIDIKWNPTANNGGA
PVTGYIVEKKEKGSAIWTEAGKTPGTTFSADNLKPGVEYEFRVIAVNAAGPSDPSDPTDP
QITKARYLKPKILTASRKIKIKAGFTHNLEVDFIGAPDPTATWTVGDSGAALAPELLVDA
KSSTTSIFFPSAKRADSGNYKLKVKNELGEDEAIFEVIVQDRPSAPEGPLEVSDVTKDSC
VLNWKPPKDDGGAEISNYVVEKRDTKTNTWVPVSAFVTGTSITVPKLTEGHEYEFRVMAE
NTFGRSDSLNTDEPVLAKDPFGTPGKPGRPEIVDTDNDHIDIKWDPPRDNGGSPVDHYDI
ERKDAKTGRWIKVNTSPVQGTAFSDTRVQKGHTYEYRVVAVNKAGPGQPSDSSAAATAKP
MHEAPKFDLDLDGKEFRVKAGEPLVITIPFTASPQPDISWTKEGGKPLAGVETTDSQTKL
VIPSTRRSDSGPVKIKAVNPYGEAEANIKITVIDKPGAPENITYPAVSRHTCTLNWDAPK
DDGGAEIAGYKIEYQEVGSQIWDKVPGLISGTAYTVRGLEHGQQYRFRIRAENAVGLSDY
CQGVPVVIKDPFDPPGAPSTPEITGYDTNQVSLAWNPPRDDGGSPILGYVVERFEKRGGG
DWAPVKMPMVKGTECIVPGLHENETYQFRVRAVNAAGHGEPSNGSEPVTCRPYVEKPGAP
DAPRVGKITKNSAELTWNRPLRDGGAPIDGYIVEKKKLGDNDWTRCNDKPVRDTAFEVKN
LGEKEEYEFRVIAVNSAGEGEPSKPSDLVLIEEQPGRPIFDINNLKDITVRAGETIQIRI
PYAGGNPKPIIDLFNGNSPIFENERTVVDVNPGEIVITTTGSKRSDAGPYKISATNKYGK
DTCKLNVFVLDAPGKPTGPIRATDIQADAMTLSWRPPKDNGGDAITNYVVEKRTPGGDWV
TVGHPVGTTLRVRNLDANTPYEFRVRAENQYGVGEPLETDDAIVAKNPFDTPGAPGQPEA
VETSEEAITLQWTRPTSDGGAPIQGYVIEKREVGSTEWTKAAFGNILDTKHRVTGLTPKK
TYEFRVAAYNAAGQGEYSVNSVPITADNAPTRPKINMGMLTRDILAYAGERAKILVPFAA
SPAPKVTFSKGENKISPTDPRVKVEYSDFLATLTIEKSELTDGGLYFVELENSQGSDSAS
IRLKVVDKPASPQHIRVEDIAPDCCTLYWMPPSSDGGSPITNYIVEKLDLRHSDGKWEKV
SSFVRNLNYTVGGLIKDNRYRFRVRAETQYGVSEPCELADVVVAKYQFEVPNQPEAPTVR
DKDSTWAELEWDPPRDGGSKIIGYQVQYRDTSSGRWINAKMDLSEQCHARVTGLRQNGEF
EFRIIAKNAAGFSKPSPPSERCQLKSRFGPPGPPIHVGAKSIGRNHCTITWMAPLEDGGS
KITGYNVEIREYGSTLWTVASDYNVREPEFTVDKLREFNDYEFRVVAINAAGKGIPSLPS
GPIKIQESGGSRPQIVVKPEDTAQPYNRRAVFTCEAVGRPEPTARWLRNGRELPESSRYR
FEASDGVYKFTIKEVWDIDAGEYTVEVSNPYGSDTATANLVVQAPPVIEKDVPNTILPSG
DLVRLKIYFSGTAPFRHSLVLNREEIDMDHPTIRIVEFDDHILITIPALSVREAGRYEYT
VSNDSGEATTGFWLNVTGLPEAPQGPLHISNIGPSTATLSWRPPVTDGGSKITSYVVEKR
DLSKDEWVTVTSNVKDMNYIVTGLFENHEYEFRVSAQNENGIGAPLVSEHPIIARLPFDP
PTSPLNLEIVQVGGDYVTLSWQRPLSDGGGRLRGYIVEKQEEEHDEWFRCNQNPSPPNNY
NVPNLIDGRKYRYRVFAVNDAGLSDLAELDQTLFQASGSGEGPKIVSPLSDLNEEVGRCV
TFECEISGSPRPEYRWFKGCKELVDTSKYTLINKGDKQVLIINDLTSDDADEYTCRATNS
SGTRSTRANLRIKTKPRVFIPPKYHGGYEAQKGETIELKIPYKAYPQGEARWTKDGEKIE
NNSKFSITTDDKFATLRISNASREDYGEYRVVVENSVGSDSGTVNVTVADVPEPPRFPII
ENILDEAVILSWKPPALDGGSLVTNYTIEKREAMGGSWSPCAKSRYTYTTIEGLRAGKQY
EFRIIAENKHGQSKPCEPTAPVLIPGDERKRRRGYDVDEQGKIVRGKGTVSSNYDNYVFD
IWKQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDK
ETVRKEIQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAV
EYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTG
TAEFAAPEVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDS
AFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLTPGNAPGRDSQIPSSRYTKIRDSI
KTKYDAWPEPLPPLGRISNYSSLRKHRPQEYSIRDAFWDRSEAQPRFIVKPYGTEVGEGQ
SANFYCRVIASSPPVVTWHKDDRELKQSVKYMKRYNGNDYGLTINRVKGDDKGEYTVRAK
NSYGTKEEIVFLNVTRHSEPLKFEPLEPMKKAPSPPRVEEFKERRSAPFFTFHLRNRLIQ
KNHQCKLTCSLQGNPNPTIEWMKDGHPVDEDRVQVSFRSGVCSLEIFNARVDDAGTYTVT
ATNDLGVDVSECVLTVQTKGGEPIPRVSSFRPRRAYDTLSTGTDVERSHSYADMRRRSLI
RDVSPDVRSAADDLKTKITNELPSFTAQLSDSETEVGGSAEFSAAVSGQPEPLIEWLHNG
ERISESDSRFRASYVAGKATLRISDAKKSDEGQYLCRASNSAGQEQTRATLTVKGDQPLL
NGHAGQAVESELRVTKHLGGEIVNNGESVTFEARVQGTPEEVLWMRNGQELTNGDKTSIS
QDGETLSFTINSADASDAGHYQLEVRSKGTNLVSVASLVVVGEKADPPVTRLPSSVSAPL
GGSTAFTIEFENVEGLTVQWFRGSEKIEKNERVKSVKTGNTFKLDIKNVEQDDDGIYVAK
VVKEKKAIAKYAAALLLV

It has several conserved domains.
See images for their information

gladiator answered 7 months ago

Why do hormones/steroids have a ligand-binding domain and a DNA-binding domain? Does it need its receptor...

Why do hormones/steroids have a ligand-binding domain and a DNA-binding domain? Does it need its receptor to attach to DNA?

If the alternate hypothesis states that µ does not equal 4,000, where is the rejection region...

If the alternate hypothesis states that µ does not equal 4,000, where is the rejection region for the hypothesis test? A. Both tails B. Lower or left tail C. Upper or right tail D. Center

1) The pGLO plasmid does not have EcoR1 sites flanking the GFP/araC region. Why is this...

1) The pGLO plasmid does not have EcoR1 sites flanking the GFP/araC region. Why is this an issue and how would it be dealt with? 2) Explain why it was necessary to "clean up" PCR products before performing restriction digestion. Predict what would have happened if we skipped this step.

1. Does your state have an individual income tax? If so, how closely does it conform...

1. Does your state have an individual income tax? If so, how closely does it conform to the federal tax? Can one deduct the federal tax in computing the state income tax? List some specific ways that the federal and state tax bases differ. What problems, if any, do these differences create in computing your taxes? What additional issues have been created in as a result of Federal Tax reform in 2017. (10 points) 2. What is the rate structure...

For the following parts, assume you have a hollowed solid where the hollow region has a...

For the following parts, assume you have a hollowed solid where the hollow region has a radius of 1/3 of the whole solid and the charge density can be expressed as ?=??2 with units of ?/?3 where r is measured in meters and β is a constant. Determine the value and units of β for the following cases: a) a sphere with outer radius of 12.0 cm and total charge of +8.73 μC and b) a cylinder with an outer...

Does globalization affect the physicians in a negative way like the way it has affected so...

Does globalization affect the physicians in a negative way like the way it has affected so many workers in the factories ?

1. Why do you think counterfeiting is so popular in places like India? Have you had...

1. Why do you think counterfeiting is so popular in places like India? Have you had any experience buying counterfeit goods? What are companies doing to fight against counterfeit products? 2. The book lists many advantages and disadvantages of small business ownership, which do you agree with the most? Would you start a business? How are websites like Kickstarter and Gofundme helping with small business ownership?

1) What term describe the region in space where there is a high probability of finding...

1) What term describe the region in space where there is a high probability of finding an electron? a) Quantum b) Dimension c) Configuration d) Orbital 2. Using the bronsted-lowry theory of acids and bases, what is the conjugate acid of HSO4? a) H2SO4 b) 2HSO4 c) HSO4 d) SO42 3.) How is the atomic mass of any element calculated? a) Protons plus electron b) Protons plus neutrons c) Electrons plus neutrons d) It is the number of protons 4.)...

1. Does your state have a statutory Patient’s Bill of Rights? Where in the statues is...

1. Does your state have a statutory Patient’s Bill of Rights? Where in the statues is it found? If your state does not have a statutory Patient’s Bill of Rights, find a state that does.. 2. Locate the Web site for the Agency for Health care Research and Quality (AHRQ). Who sponsors this web site? What is the purpose? Find a t least two important studies about health care access and summarize the cases.

1.) Is education a public good? Does education have external benefits? If so, what are some...

1.) Is education a public good? Does education have external benefits? If so, what are some of those public benefits? In your opinion are the external benefits large or small? Why? 2.) What should government do to promote the efficient provision of products that have external benefits? If you think that government should put more resources into education, what might be some of the opportunity costs of that decision? How would an economist determine the right amount of government support...

Question