Regarding A1C blood testing, which of the following are TRUE? SELECT ALL THAT APPLY (You may...

Regarding A1C blood testing, which of the following are TRUE? SELECT ALL THAT APPLY

(You may need to consult additional resources)

A		Is a direct measurement of blood glucose concentrations
B		Represents the fraction of hemoglobin containing bound monosaccharides
C		Estimates blood glucose concentrations over a 2-3 month period
D		Cannot provide reliable data to support a diagnosis

Expert Solution

Ans:- B , C , and D are correct.

A) is incorrect because HbA1c is indirect measurent of glucose by using Heamiglobin.

B) is correct because HbA1C i.e called glycelated Heamiglobin is formed when glucose ( monosaccharide) bound to Haemoglobin.

C) as life spans of RBC is 2-3 months so it tell about the glucose statust if 2-3 months.

D) HbA1C can't provide realiable data to support diagnosis, it is generally use to monitor how much blood sugar is controlled in diabetes pt.

It has following flause so it can't be use to support diagonosis.:-

1. Rapid onset of diabetes – an increase in HbA1c may not be detected until a few weeks later. a. Suspected type 1 diabetes – rapid onset of symptoms, weight loss, ketosis. b. Children – because most will have type 1 diabetes. c. Steroids. Antipsychotics & immunosuppressants can raise blood glucose, rarely precipitously. d. After pancreatitis or pancreatic surgery.

2. Pregnancy. Multiple factors make HbA1c lower in pregnancy. The diagnosis of gestational diabetes should be made on blood glucose, in line.

3. Conditions with reduced red survival may lower HbA1c: a. Haemoglobinopathy which will normally be detected by the lab, but should be suspected in racial groups where there is a high prevalence of sickle trait, sickle disease or thalassaemia.

b. Haemolytic anaemia c. Severe blood loss d. Splenomegaly e. Antiretroviral drugs

4. Increased red cell survival may increase HbA1c e.g. splenectomy.

5. Renal dialysis patients have a markedly reduced HbA1c especially if treated with erythropoietin.
6. Iron and B12 deficiency and their treatment. May raise or lower HbA1c, but the effect is small.

Sydney Mullin answered 8 months ago

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