Question

what happens to STDP(spike timing dependent plasticity) if all biological neuron in brain just generate IPSP(inhibitory postsynaptic potential) don't generate EPSP(excitatory postsynaptic potential)?
Please explain what happens specifically and the reason of it.

Answer 1

An IPSP is received when an inhibitory presynaptic cell, connected to the dendrite, fires am action potential. The IPSP signal is propagated down the dendrite and is summed with other inputs at the axon hillock. The IPSP decreases the neurons membrane potential and makes more likely for an action potential to occur.

An EPSP is a temporary depolarization of postsynaptic membrane caused by the flow of positively charged ions into the postsynaptic cell as a result of opening of ligand sensitive channels. An EPSP is received when an excitatory presynaptic cell, connected to the dendrites fires an action potential. The strength of the EPSP depend on the distance from the soma. The signal degrades across the dendrite such that the more proximal connections have more of an influence.

An IPSP is a temporary hyperpolarization of postsynaptic membrane caused by the flow of negatively charged ions into the postsynaptic cell. An IPSP is received when an inhibitory presynaptic cell, connected to the dendrite, fires an action potential. A postsynaptic cell typically has less inhibitory connections but the connections are closer to the soma. The proximity of the inhibitory connections produces a stronger signal such that fewer IPSPs are needed to cancel out the effect of EPSPs.