Question

1. Imitants that aggravate the skin of persons with atopic dermatitis are
A. cotton and silk
B. perfumes and cosmetics
C. rice and potatoes
D. cleaning solvents and detergents
E. B and D

2. Psoriatic patches are typically found in all of the regions except

A. neck
B. face
C. elbows
D. genitals
E. hands and feet

3. Which advice would not be given to a person with eczema?

A. Avoid wearing wool or clothing that feels "scratchy."
B. Increase humidity in the household environment. C. Apply moisturizers and lotion to the
D. Take hot baths.

4. Of the following, the most potent corticosteroid classification is

A. class I
B. class II
C. class III
D. class IV

5. Select the corticosteroid that is in the least potent category.

A. clobetasol
B. betamethasone dipropionate (optimized)
C. hydrocortisone base cream
D. halobetasol propionate
E. fluocinonide

6. Which of the following adverse effects is not linked
to topical use of corticosteroids?

A. thinning of the skin
B. Cushing's syndrome
C. stretch marks (striae)
D. spider veins
E. acne

7. Select the drug that is indicated for the treatment of severe psoriasis and arthritis.

A. cyclosporine
B. azathioprine
C. methotrexate
D. calcipotriene

Which of the following correctly describes the mechanism of action of topical corticosteroids?

A. Corticosteroids decrease redness, swelling, and inflammation by reducing the number of inflammatory cells.
B. Corticosteroids increase cell permeability to T lymphocytes and eosinophils.
C. Corticosteroids increase cytokine release.
D. Topical corticosteroids cause vasodilation.

9. The FDA and Health Canada require manufacturers to include a Black Box warning in the package insert for_____, describing the increased risks for cancer.

A. Dermatop-E and Dovonex
B. Cutivate and Ultravate
C. methotrexate and Enbrel
D. pimecrolimus and tacrolimus

Answer 1

1- B and D

Things that can worsen the skinreaction include sweat, stress, obesity, soaps, detergents, dust and pollen. Reduce your exposure to your triggers. Infants and children may experience flares from eating certain foods, including eggs, milk, soy and wheat.

2- D

Psoriasis is an autoimmune disease that causes plaques, which are itchy or sore patches of thick, red, dry skin. While any part of your body can be affected, psoriasis plaques most often develop on the elbows, knees, scalp, back, face, palms, and feet.

3- D

People with eczema should avoid harsh cleansers, drink water often, wear gloves in cold weather, and avoid wearing materials such as wool, which could irritate the skin. Flare-ups of eczema can be caused by foods, cosmetics, soaps, wool, dust mites, mold, pollen, dog or cat dander, dry climate and other variables.

4-A

Classification systems

Class I is the strongest, or superpotent. Class VII is the weakest and mildest.

5- C

These topical steroids are considered the least potent:

• Hydrocortisone 2.5% (Hytone cream/lotion)
• Hydrocortisone 1% (Many over-the-counter brands of creams, ointments, lotions)
• Hydrocortisone acetate 0.5% and 1% (Anusol-HC, Proctocream-HC, Proctosol HC cream)

6-B

With long-term use of topical steroid the skin may develop permanent stretch marks (striae), bruising, discolouration, or thin spidery blood vessels (telangiectasias). Topical steroids may trigger or worsen other skin disorders such as acne, rosacea and perioral dermatitis.

7-C

These drugs can slow the progression of psoriatic arthritis and save the joints and other tissues from permanent damage. Common DMARDs include methotrexate (Trexall, Otrexup, others), leflunomide (Arava) and sulfasalazine (Azulfidine).

8-A

Corticosteroids modify the functions of epidermal and dermal cells and of leukocytes participating in proliferative and inflammatory skin diseases. After passage through the cell membrane corticosteroids react with receptor proteins in the cytoplasm to form a steroid-receptor complex.

9-C

Drug class	Drug name
Miscellaneous antipsychotic agents	Seroquel (quetiapine fumarate)
Certain analgesics/narcotics	OxyContin (oxycodone)
Antibiotics (fluoroquinolones)	Levaquin(levofloxacin)
Antimetabolites or folic acid antagonists	Methotrexate