1. What types of drugs are likely to display two-compartment elimination kinetics behavior. Give reason support...

1. What types of drugs are likely to display two-compartment elimination kinetics behavior. Give reason support your answer.

2. Explain why the distribution phase rate constant is greater than the elimination phase rate constant.

pharmacokinetics problems.

Expert Solution

1) Ans- A two compartment model is used for drugs which distribute slowly within the body. This model also called two compartment open model where drugs can enter and leave the body. For example, incase of a one time bolus IV administration over a short time period could lead to a drug distribution rapidly in blood and also to highly perfused body organs like liver and kidneys. There would be slower distribution to other parts of the body as the second compartment.

Two examples of drugs are vancomycin and digoxin. The drug and other substance enters in body and distributes in the first compartment. It is then distributes to another compartment. The concentration in first compartment declines with time whereas the concentration in the second compartment rises, peaks and declines as the chemical is eliminated from the body. In pharmacokinetic model the half life for a chemical is considered as biological half-life . This is the most commonly used measure of the kinetic behaviour of a xenobiotic.

** Dear student as per rules I have to do only one question. Thank you!

gladiator answered 2 years ago

Give two reasons that support the independence of the Federal Reserve Bank and two reason against...

Give two reasons that support the independence of the Federal Reserve Bank and two reason against such independence.

a) In the decarboxylative elimination, two different solvents are used, butanone and water. What types of...

a) In the decarboxylative elimination, two different solvents are used, butanone and water. What types of solvents are these and why is that important for the ultimate course of reaction in each case? b) Starting with (R,R)-2-3-dibromo-3-phenylpropanoic acid, which alkene products you would expect to observe if doing the reaction in water? How about in butanone? Provide reaction mechanisms to support your answers. be different. c) which alkene product would be expected if (S,S)-2,3-dibromo-3-phenylpropanoic acid isomer was used as a...

Write an essay about: what is consumer behavior? Give examples of the types of questions about...

Write an essay about: what is consumer behavior? Give examples of the types of questions about consumer behavior that marketers investigate

What are the advantages and disadvantages of stock buyback? Give 1 reason for each.

2-What are the three primary types of cost behavior and how do they differ? 3-Give an...

2-What are the three primary types of cost behavior and how do they differ? 3-Give an example of variable cost. 4-Give an example of a fixed cost 5- Give an example of a mixed cost 6- What is the contribution margin? 11-What is the breakeven point? 12-How do you compute the breakeven point in dollars? • Exercises and problems 1, 2, 3, 4 (replace your workplace with “pizza shop”), 5, 9, 10 1-Classify the following costs as fixed, variable, or...

1. What types of costs are allocated? What is a support department? What is a producing...

1. What types of costs are allocated? What is a support department? What is a producing department? What types of costs are allocated? Why is cost allocation important for companies to consider? 2. What are the differences between single charging rate and multiple charging rates? What factors might a company consider when determining how to allocate support department costs to a producing department? Give some examples of a type of support department costs and why it might be reasonably allocated...

1) Historically, Stocks have returned more than bonds and cash. What is the likely reason for...

1) Historically, Stocks have returned more than bonds and cash. What is the likely reason for the return differences between cash, fixed income, and equities?

1.Give two reasons why a banking crisis is likely to result in a recession in the...

1.Give two reasons why a banking crisis is likely to result in a recession in the “real economy”. 2.(a)Suppose you have $400,000 in a deposit account at a Canadian bank that has just been declared insolvent. Would you prefer that the Canadian Deposit Insurance Corporation (CDIC) resolve the solvency under the “winding up method” or the “purchase and assumption” method? Explain your choice. (b) Suppose instead you are a shareholder in the now insolvent bank. Answer the question from part...

Give the PowerShell command that would display the “Path” environment variable. What two PowerShell commands will...

Give the PowerShell command that would display the “Path” environment variable. What two PowerShell commands will display all of the users currently logged into a server? What command would give helpful information about the Get-Command cmdlet.

What is electroporation? What are the two types of electroporation? Give two applications for each type....

What is electroporation? What are the two types of electroporation? Give two applications for each type. Comment on the electric pulse duration and magnitude used for introduction of small molecules vs. larger molecules?

Question