In: Biology
Do pesticides even at a non-toxic dose bioaccumulate in animal and plant tissue?
Also do metabolite changes in plants for herbivore defense causes similar fluctations in p450 expression? the sub-lethal stress (ie parasites, pathogens and habitat loss) may change expression. Does exposure to this growing list of factors detract from pesticide defense by p450?
Bioaccumulation can occur even at a non toxic dose and depends on the half life of the chemical contained within the pesticide. It happens when the rate of accumulation is greater than rate of catabolism.
The metabolite changes in plants lead to changes in cytochrome p450 expression as the enzyme catalysses a series of reactions and contribute to the chemical defense of plants. The fluctuations of p450 again depends on multiple factors like concentration of toxic or non toxic compunds, substrates which needs to be converted into metabolites. If the concentration of toxic compounds increases, p450 expression increases and the enzymatic activity will be channeled more towards catalysing those compunds into less harmful ones.
The ability to balance the pesticide defense against many other abiotic/biotic factors would reduce the ability of fight against the harmful effects of pesticide. Ultimately, the decision needs to be taken by the plant as to which needs to be taken care more. Harmful effects of pesticide will be more potent than other factors. If the metabolic pathway shifts towards reducing the effect of other factors, ability to fight against pesticide may go down.